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RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer.
Spit M, Fenderico N, Jordens I, Radaszkiewicz T, Lindeboom RG, Bugter JM, Cristobal A, Ootes L, van Osch M, Janssen E, Boonekamp KE, Hanakova K, Potesil D, Zdrahal Z, Boj SF, Medema JP, Bryja V, Koo BK, Vermeulen M, Maurice MM. Spit M, et al. Among authors: maurice mm. EMBO J. 2020 Sep 15;39(18):e103932. doi: 10.15252/embj.2019103932. Epub 2020 Aug 10. EMBO J. 2020. PMID: 32965059 Free PMC article.
Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled.
Tauriello DV, Jordens I, Kirchner K, Slootstra JW, Kruitwagen T, Bouwman BA, Noutsou M, Rüdiger SG, Schwamborn K, Schambony A, Maurice MM. Tauriello DV, et al. Among authors: maurice mm. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):E812-20. doi: 10.1073/pnas.1114802109. Epub 2012 Mar 12. Proc Natl Acad Sci U S A. 2012. PMID: 22411803 Free PMC article.
Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network.
Anvarian Z, Nojima H, van Kappel EC, Madl T, Spit M, Viertler M, Jordens I, Low TY, van Scherpenzeel RC, Kuper I, Richter K, Heck AJ, Boelens R, Vincent JP, Rüdiger SG, Maurice MM. Anvarian Z, et al. Among authors: maurice mm. Nat Struct Mol Biol. 2016 Apr;23(4):324-32. doi: 10.1038/nsmb.3191. Epub 2016 Mar 14. Nat Struct Mol Biol. 2016. PMID: 26974125
Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene.
Oost KC, van Voorthuijsen L, Fumagalli A, Lindeboom RGH, Sprangers J, Omerzu M, Rodriguez-Colman MJ, Heinz MC, Verlaan-Klink I, Maurice MM, Burgering BMT, van Rheenen J, Vermeulen M, Snippert HJG. Oost KC, et al. Among authors: maurice mm. Cell Rep. 2018 Feb 6;22(6):1600-1614. doi: 10.1016/j.celrep.2018.01.033. Cell Rep. 2018. PMID: 29425513 Free PMC article.
TMEM59 potentiates Wnt signaling by promoting signalosome formation.
Gerlach JP, Jordens I, Tauriello DVF, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJR, Egan DA, Maurice MM. Gerlach JP, et al. Among authors: maurice mm. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3996-E4005. doi: 10.1073/pnas.1721321115. Epub 2018 Apr 9. Proc Natl Acad Sci U S A. 2018. PMID: 29632210 Free PMC article.
Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.
Fenderico N, van Scherpenzeel RC, Goldflam M, Proverbio D, Jordens I, Kralj T, Stryeck S, Bass TZ, Hermans G, Ullman C, Aastrup T, Gros P, Maurice MM. Fenderico N, et al. Among authors: maurice mm. Nat Commun. 2019 Jan 21;10(1):365. doi: 10.1038/s41467-018-08172-z. Nat Commun. 2019. PMID: 30664649 Free PMC article.
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