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The detection of isochromosome i(12p) in malignant germ cell tumours and tumours with somatic malignant transformation by the use of quantitative real-time polymerase chain reaction.
Fichtner A, Richter A, Filmar S, Gaisa NT, Schweyer S, Reis H, Nettersheim D, Oing C, Gayer FA, Leha A, Küffer S, Ströbel P, Kaulfuß S, Bremmer F. Fichtner A, et al. Among authors: nettersheim d. Histopathology. 2021 Mar;78(4):593-606. doi: 10.1111/his.14258. Epub 2020 Nov 21. Histopathology. 2021. PMID: 32970854
CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms.
Skowron MA, Vermeulen M, Winkelhausen A, Becker TK, Bremmer F, Petzsch P, Schönberger S, Calaminus G, Köhrer K, Albers P, Nettersheim D. Skowron MA, et al. Among authors: nettersheim d. Br J Cancer. 2020 Aug;123(3):378-391. doi: 10.1038/s41416-020-0891-x. Epub 2020 May 18. Br J Cancer. 2020. PMID: 32418994 Free PMC article.
Efficacy of HDAC Inhibitors Belinostat and Panobinostat against Cisplatin-Sensitive and Cisplatin-Resistant Testicular Germ Cell Tumors.
Lobo J, Guimarães-Teixeira C, Barros-Silva D, Miranda-Gonçalves V, Camilo V, Guimarães R, Cantante M, Braga I, Maurício J, Oing C, Honecker F, Nettersheim D, Looijenga LH, Henrique R, Jerónimo C. Lobo J, et al. Among authors: nettersheim d. Cancers (Basel). 2020 Oct 10;12(10):2903. doi: 10.3390/cancers12102903. Cancers (Basel). 2020. PMID: 33050470 Free PMC article.
The pioneer and differentiation factor FOXA2 is a key driver of yolk-sac tumour formation and a new biomarker for paediatric and adult yolk-sac tumours.
Wruck W, Bremmer F, Kotthoff M, Fichtner A, Skowron MA, Schönberger S, Calaminus G, Vokuhl C, Pfister D, Heidenreich A, Albers P, Adjaye J, Nettersheim D. Wruck W, et al. Among authors: nettersheim d. J Cell Mol Med. 2021 Feb;25(3):1394-1405. doi: 10.1111/jcmm.16222. Epub 2021 Jan 14. J Cell Mol Med. 2021. PMID: 33448076 Free PMC article.
The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas.
Skowron MA, Becker TK, Kurz L, Jostes S, Bremmer F, Fronhoffs F, Funke K, Wakileh GA, Müller MR, Burmeister A, Lenz T, Stefanski A, Stühler K, Petzsch P, Köhrer K, Altevogt P, Albers P, Kristiansen G, Schorle H, Nettersheim D. Skowron MA, et al. Among authors: nettersheim d. Mol Oncol. 2022 Feb;16(4):982-1008. doi: 10.1002/1878-0261.13066. Epub 2021 Aug 2. Mol Oncol. 2022. PMID: 34293822 Free PMC article.
The developmental origin of cancers defines basic principles of cisplatin resistance.
Skowron MA, Oing C, Bremmer F, Ströbel P, Murray MJ, Coleman N, Amatruda JF, Honecker F, Bokemeyer C, Albers P, Nettersheim D. Skowron MA, et al. Among authors: nettersheim d. Cancer Lett. 2021 Oct 28;519:199-210. doi: 10.1016/j.canlet.2021.07.037. Epub 2021 Jul 25. Cancer Lett. 2021. PMID: 34320371 Review.
The component of the m6A writer complex VIRMA is implicated in aggressive tumor phenotype, DNA damage response and cisplatin resistance in germ cell tumors.
Miranda-Gonçalves V, Lobo J, Guimarães-Teixeira C, Barros-Silva D, Guimarães R, Cantante M, Braga I, Maurício J, Oing C, Honecker F, Nettersheim D, Looijenga LHJ, Henrique R, Jerónimo C. Miranda-Gonçalves V, et al. Among authors: nettersheim d. J Exp Clin Cancer Res. 2021 Aug 25;40(1):268. doi: 10.1186/s13046-021-02072-9. J Exp Clin Cancer Res. 2021. PMID: 34446080 Free PMC article.
70 results