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Spatial transcriptomic patterns underlying regional vulnerability to amyloid-β and tau pathologies and their relationships to cognitive dysfunction in Alzheimer's disease.
Yu M, Risacher SL, Nho KT, Wen Q, Oblak AL, Unverzagt FW, Apostolova LG, Farlow MR, Brosch JR, Clark DG, Wang S, Deardorff R, Wu YC, Gao S, Sporns O, Saykin AJ; Alzheimer’s Disease Neuroimaging Initiative (ADNI). Yu M, et al. Among authors: oblak al. medRxiv [Preprint]. 2023 Aug 16:2023.08.12.23294017. doi: 10.1101/2023.08.12.23294017. medRxiv. 2023. PMID: 37645867 Free PMC article. Preprint.
Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice.
Jadhav VS, Lin PBC, Pennington T, Di Prisco GV, Jannu AJ, Xu G, Moutinho M, Zhang J, Atwood BK, Puntambekar SS, Bissel SJ, Oblak AL, Landreth GE, Lamb BT. Jadhav VS, et al. Among authors: oblak al. Mol Neurodegener. 2020 Oct 28;15(1):62. doi: 10.1186/s13024-020-00409-0. Mol Neurodegener. 2020. PMID: 33115519 Free PMC article.
A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease.
Preuss C, Pandey R, Piazza E, Fine A, Uyar A, Perumal T, Garceau D, Kotredes KP, Williams H, Mangravite LM, Lamb BT, Oblak AL, Howell GR, Sasner M, Logsdon BA; MODEL-AD Consortium; Carter GW. Preuss C, et al. Among authors: oblak al. Mol Neurodegener. 2020 Nov 10;15(1):67. doi: 10.1186/s13024-020-00412-5. Mol Neurodegener. 2020. PMID: 33172468 Free PMC article.
Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study.
Oblak AL, Lin PB, Kotredes KP, Pandey RS, Garceau D, Williams HM, Uyar A, O'Rourke R, O'Rourke S, Ingraham C, Bednarczyk D, Belanger M, Cope ZA, Little GJ, Williams SG, Ash C, Bleckert A, Ragan T, Logsdon BA, Mangravite LM, Sukoff Rizzo SJ, Territo PR, Carter GW, Howell GR, Sasner M, Lamb BT. Oblak AL, et al. Front Aging Neurosci. 2021 Jul 23;13:713726. doi: 10.3389/fnagi.2021.713726. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34366832 Free PMC article.
Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H.
Kotredes KP, Oblak A, Pandey RS, Lin PB, Garceau D, Williams H, Uyar A, O'Rourke R, O'Rourke S, Ingraham C, Bednarycek D, Belanger M, Cope Z, Foley KE, Logsdon BA, Mangravite LM, Sukoff Rizzo SJ, Territo PR, Carter GW, Sasner M, Lamb BT, Howell GR. Kotredes KP, et al. Front Aging Neurosci. 2021 Oct 11;13:735524. doi: 10.3389/fnagi.2021.735524. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34707490 Free PMC article.
Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer's disease in a mouse model of Aβ amyloidosis.
Karahan H, Smith DC, Kim B, Dabin LC, Al-Amin MM, Wijeratne HRS, Pennington T, Viana di Prisco G, McCord B, Lin PB, Li Y, Peng J, Oblak AL, Chu S, Atwood BK, Kim J. Karahan H, et al. Among authors: oblak al, al amin mm. Sci Adv. 2021 Nov 5;7(45):eabe3954. doi: 10.1126/sciadv.abe3954. Epub 2021 Nov 3. Sci Adv. 2021. PMID: 34731000 Free PMC article.
73 results