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Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity.
Newell F, Wilmott JS, Johansson PA, Nones K, Addala V, Mukhopadhyay P, Broit N, Amato CM, Van Gulick R, Kazakoff SH, Patch AM, Koufariotis LT, Lakis V, Leonard C, Wood S, Holmes O, Xu Q, Lewis K, Medina T, Gonzalez R, Saw RPM, Spillane AJ, Stretch JR, Rawson RV, Ferguson PM, Dodds TJ, Thompson JF, Long GV, Levesque MP, Robinson WA, Pearson JV, Mann GJ, Scolyer RA, Waddell N, Hayward NK. Newell F, et al. Among authors: levesque mp. Nat Commun. 2020 Oct 16;11(1):5259. doi: 10.1038/s41467-020-18988-3. Nat Commun. 2020. PMID: 33067454 Free PMC article.
Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation.
Kim H, Frederick DT, Levesque MP, Cooper ZA, Feng Y, Krepler C, Brill L, Samuels Y, Hayward NK, Perlina A, Piris A, Zhang T, Halaban R, Herlyn MM, Brown KM, Wargo JA, Dummer R, Flaherty KT, Ronai ZA. Kim H, et al. Among authors: levesque mp. Cell Rep. 2015 Jun 9;11(9):1458-73. doi: 10.1016/j.celrep.2015.04.049. Epub 2015 May 28. Cell Rep. 2015. PMID: 26027934 Free PMC article.
Noncutaneous Melanomas: A Single-Center Analysis.
Del Prete V, Chaloupka K, Holzmann D, Fink D, Levesque M, Dummer R, Goldinger SM. Del Prete V, et al. Dermatology. 2016;232(1):22-9. doi: 10.1159/000441444. Epub 2015 Dec 1. Dermatology. 2016. PMID: 26618350 Free article.
A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis.
Claps G, Cheli Y, Zhang T, Scortegagna M, Lau E, Kim H, Qi J, Li JL, James B, Dzung A, Levesque MP, Dummer R, Hayward NK, Bosenberg M, Brown KM, Ronai ZA. Claps G, et al. Among authors: levesque mp. Cell Rep. 2016 May 31;15(9):1884-92. doi: 10.1016/j.celrep.2016.04.072. Epub 2016 May 19. Cell Rep. 2016. PMID: 27210757 Free PMC article.
Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets.
Newell F, Kong Y, Wilmott JS, Johansson PA, Ferguson PM, Cui C, Li Z, Kazakoff SH, Burke H, Dodds TJ, Patch AM, Nones K, Tembe V, Shang P, van der Weyden L, Wong K, Holmes O, Lo S, Leonard C, Wood S, Xu Q, Rawson RV, Mukhopadhyay P, Dummer R, Levesque MP, Jönsson G, Wang X, Yeh I, Wu H, Joseph N, Bastian BC, Long GV, Spillane AJ, Shannon KF, Thompson JF, Saw RPM, Adams DJ, Si L, Pearson JV, Hayward NK, Waddell N, Mann GJ, Guo J, Scolyer RA. Newell F, et al. Among authors: levesque mp. Nat Commun. 2019 Jul 18;10(1):3163. doi: 10.1038/s41467-019-11107-x. Nat Commun. 2019. PMID: 31320640 Free PMC article.
Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases.
Rabbie R, Ansari-Pour N, Cast O, Lau D, Scott F, Welsh SJ, Parkinson C, Khoja L, Moore L, Tullett M, Wong K, Ferreira I, Gómez JMM, Levesque M, Gallagher FA, Jiménez-Sánchez A, Riva L, Miller ML, Allinson K, Campbell PJ, Corrie P, Wedge DC, Adams DJ. Rabbie R, et al. Nat Commun. 2020 Aug 27;11(1):4306. doi: 10.1038/s41467-020-18060-0. Nat Commun. 2020. PMID: 32855398 Free PMC article.
Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling.
Vergara IA, Mintoff CP, Sandhu S, McIntosh L, Young RJ, Wong SQ, Colebatch A, Cameron DL, Kwon JL, Wolfe R, Peng A, Ellul J, Dou X, Fedele C, Boyle S, Arnau GM, Raleigh J, Hatzimihalis A, Szeto P, Mooi J, Widmer DS, Cheng PF, Amann V, Dummer R, Hayward N, Wilmott J, Scolyer RA, Cho RJ, Bowtell D, Thorne H, Alsop K, Cordner S, Woodford N, Leditschke J, O'Brien P, Dawson SJ, McArthur GA, Mann GJ, Levesque MP, Papenfuss AT, Shackleton M. Vergara IA, et al. Among authors: levesque mp. Nat Commun. 2021 Mar 4;12(1):1434. doi: 10.1038/s41467-021-21576-8. Nat Commun. 2021. PMID: 33664264 Free PMC article.
Combined presentation and immunogenicity analysis reveals a recurrent RAS.Q61K neoantigen in melanoma.
Peri A, Greenstein E, Alon M, Pai JA, Dingjan T, Reich-Zeliger S, Barnea E, Barbolin C, Levy R, Arnedo-Pac C, Kalaora S, Dassa B, Feldmesser E, Shang P, Greenberg P, Levin Y, Benedek G, Levesque MP, Adams DJ, Lotem M, Wilmott JS, Scolyer RA, Jönsson GB, Admon A, Rosenberg SA, Cohen CJ, Niv MY, Lopez-Bigas N, Satpathy AT, Friedman N, Samuels Y. Peri A, et al. Among authors: levesque mp. J Clin Invest. 2021 Oct 15;131(20):e129466. doi: 10.1172/JCI129466. J Clin Invest. 2021. PMID: 34651586 Free PMC article.
The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.
Zingg D, Debbache J, Schaefer SM, Tuncer E, Frommel SC, Cheng P, Arenas-Ramirez N, Haeusel J, Zhang Y, Bonalli M, McCabe MT, Creasy CL, Levesque MP, Boyman O, Santoro R, Shakhova O, Dummer R, Sommer L. Zingg D, et al. Among authors: levesque mp. Nat Commun. 2015 Jan 22;6:6051. doi: 10.1038/ncomms7051. Nat Commun. 2015. PMID: 25609585 Free article.
219 results