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Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype-Derived Activity Scores.
Thomas CD, Mosley SA, Kim S, Lingineni K, El Rouby N, Langaee TY, Gong Y, Wang D, Schmidt SO, Binkley PF, Estores DS, Feng K, Kim H, Kinjo M, Li Z, Fang L, Chapman AB, Cooper-DeHoff RM, Gums JG, Hamadeh IS, Zhao L, Schmidt S, Frye RF, Johnson JA, Cavallari LH. Thomas CD, et al. Among authors: el rouby n. CPT Pharmacometrics Syst Pharmacol. 2020 Dec;9(12):678-685. doi: 10.1002/psp4.12563. Epub 2020 Nov 3. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 33067866 Free PMC article. Clinical Trial.
A randomized, cross-over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence.
Mosley SA, Kim S, El Rouby N, Lingineni K, Esteban VV, Gong Y, Chen Y, Estores D, Feng K, Kim H, Kinjo M, Langaee T, Li Z, Schmidt SOF, Johnson JA, Frye RF, Fang LL, Zhao L, Binkley PF, Schmidt S, Cavallari LH. Mosley SA, et al. Among authors: el rouby n. Clin Transl Sci. 2022 Jul;15(7):1764-1775. doi: 10.1111/cts.13294. Epub 2022 May 21. Clin Transl Sci. 2022. PMID: 35488487 Free PMC article. Clinical Trial.
PTPRD gene associated with blood pressure response to atenolol and resistant hypertension.
Gong Y, McDonough CW, Beitelshees AL, El Rouby N, Hiltunen TP, O'Connell JR, Padmanabhan S, Langaee TY, Hall K, Schmidt SO, Curry RW Jr, Gums JG, Donner KM, Kontula KK, Bailey KR, Boerwinkle E, Takahashi A, Tanaka T, Kubo M, Chapman AB, Turner ST, Pepine CJ, Cooper-DeHoff RM, Johnson JA. Gong Y, et al. Among authors: el rouby n. J Hypertens. 2015 Nov;33(11):2278-85. doi: 10.1097/HJH.0000000000000714. J Hypertens. 2015. PMID: 26425837 Free PMC article.
Atenolol induced HDL-C change in the pharmacogenomic evaluation of antihypertensive responses (PEAR) study.
McDonough CW, Gillis NK, Alsultan A, Chang SW, Kawaguchi-Suzuki M, Lang JE, Shahin MH, Buford TW, El Rouby NM, Sá AC, Langaee TY, Gums JG, Chapman AB, Cooper-DeHoff RM, Turner ST, Gong Y, Johnson JA. McDonough CW, et al. PLoS One. 2013 Oct 7;8(10):e76984. doi: 10.1371/journal.pone.0076984. eCollection 2013. PLoS One. 2013. PMID: 24116192 Free PMC article.
Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses).
McDonough CW, Magvanjav O, Sá ACC, El Rouby NM, Dave C, Deitchman AN, Kawaguchi-Suzuki M, Mei W, Shen Y, Singh RSP, Solayman M, Bailey KR, Boerwinkle E, Chapman AB, Gums JG, Webb A, Scherer SE, Sadee W, Turner ST, Cooper-DeHoff RM, Gong Y, Johnson JA. McDonough CW, et al. Among authors: el rouby nm. Circ Genom Precis Med. 2018 Apr;11(4):e001854. doi: 10.1161/CIRCGEN.117.001854. Circ Genom Precis Med. 2018. PMID: 29650764 Free PMC article. Clinical Trial.
31 results