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Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death.
Richards KL, Milligan CJ, Richardson RJ, Jancovski N, Grunnet M, Jacobson LH, Undheim EAB, Mobli M, Chow CY, Herzig V, Csoti A, Panyi G, Reid CA, King GF, Petrou S. Richards KL, et al. Among authors: jancovski n. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8077-E8085. doi: 10.1073/pnas.1804764115. Epub 2018 Aug 3. Proc Natl Acad Sci U S A. 2018. PMID: 30076230 Free PMC article.
Antisense oligonucleotide therapy reduces seizures and extends life span in an SCN2A gain-of-function epilepsy model.
Li M, Jancovski N, Jafar-Nejad P, Burbano LE, Rollo B, Richards K, Drew L, Sedo A, Heighway J, Pachernegg S, Soriano A, Jia L, Blackburn T, Roberts B, Nemiroff A, Dalby K, Maljevic S, Reid CA, Rigo F, Petrou S. Li M, et al. Among authors: jancovski n. J Clin Invest. 2021 Dec 1;131(23):e152079. doi: 10.1172/JCI152079. J Clin Invest. 2021. PMID: 34850743 Free PMC article.
Antisense oligonucleotide therapy for KCNT1 encephalopathy.
Burbano LE, Li M, Jancovski N, Jafar-Nejad P, Richards K, Sedo A, Soriano A, Rollo B, Jia L, Gazina EV, Piltz S, Adikusuma F, Thomas PQ, Kopsidas H, Rigo F, Reid CA, Maljevic S, Petrou S. Burbano LE, et al. Among authors: jancovski n. JCI Insight. 2022 Dec 8;7(23):e146090. doi: 10.1172/jci.insight.146090. JCI Insight. 2022. PMID: 36173683 Free PMC article.
Carbogen-Induced Respiratory Acidosis Blocks Experimental Seizures by a Direct and Specific Inhibition of NaV1.2 Channels in the Axon Initial Segment of Pyramidal Neurons.
Hatch RJ, Berecki G, Jancovski N, Li M, Rollo B, Jafar-Nejad P, Rigo F, Kaila K, Reid CA, Petrou S. Hatch RJ, et al. Among authors: jancovski n. J Neurosci. 2023 Mar 8;43(10):1658-1667. doi: 10.1523/JNEUROSCI.1387-22.2022. Epub 2023 Feb 2. J Neurosci. 2023. PMID: 36732074 Free PMC article.
Excessive Respiratory Modulation of Blood Pressure Triggers Hypertension.
Menuet C, Le S, Dempsey B, Connelly AA, Kamar JL, Jancovski N, Bassi JK, Walters K, Simms AE, Hammond A, Fong AY, Goodchild AK, McMullan S, Allen AM. Menuet C, et al. Among authors: jancovski n. Cell Metab. 2017 Mar 7;25(3):739-748. doi: 10.1016/j.cmet.2017.01.019. Epub 2017 Feb 16. Cell Metab. 2017. PMID: 28215844 Free article.
18 results