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A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection.
Wright SC, Kozielewicz P, Kowalski-Jahn M, Petersen J, Bowin CF, Slodkowicz G, Marti-Solano M, Rodríguez D, Hot B, Okashah N, Strakova K, Valnohova J, Babu MM, Lambert NA, Carlsson J, Schulte G. Wright SC, et al. Among authors: babu mm. Nat Commun. 2019 Feb 8;10(1):667. doi: 10.1038/s41467-019-08630-2. Nat Commun. 2019. PMID: 30737406 Free PMC article.
Combinatorial expression of GPCR isoforms affects signalling and drug responses.
Marti-Solano M, Crilly SE, Malinverni D, Munk C, Harris M, Pearce A, Quon T, Mackenzie AE, Wang X, Peng J, Tobin AB, Ladds G, Milligan G, Gloriam DE, Puthenveedu MA, Babu MM. Marti-Solano M, et al. Among authors: babu mm. Nature. 2020 Nov;587(7835):650-656. doi: 10.1038/s41586-020-2888-2. Epub 2020 Nov 4. Nature. 2020. PMID: 33149304 Free PMC article.
Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.
Brouwers B, de Oliveira EM, Marti-Solano M, Monteiro FBF, Laurin SA, Keogh JM, Henning E, Bounds R, Daly CA, Houston S, Ayinampudi V, Wasiluk N, Clarke D, Plouffe B, Bouvier M, Babu MM, Farooqi IS, Mokrosiński J. Brouwers B, et al. Among authors: babu mm. Cell Rep. 2021 Mar 23;34(12):108862. doi: 10.1016/j.celrep.2021.108862. Cell Rep. 2021. PMID: 33761344 Free PMC article.
Molecular determinants of ligand efficacy and potency in GPCR signaling.
Heydenreich FM, Marti-Solano M, Sandhu M, Kobilka BK, Bouvier M, Babu MM. Heydenreich FM, et al. Among authors: babu mm. Science. 2023 Dec 22;382(6677):eadh1859. doi: 10.1126/science.adh1859. Epub 2023 Dec 22. Science. 2023. PMID: 38127743 Free PMC article.
A Global Map of G Protein Signaling Regulation by RGS Proteins.
Masuho I, Balaji S, Muntean BS, Skamangas NK, Chavali S, Tesmer JJG, Babu MM, Martemyanov KA. Masuho I, et al. Among authors: babu mm. Cell. 2020 Oct 15;183(2):503-521.e19. doi: 10.1016/j.cell.2020.08.052. Epub 2020 Oct 1. Cell. 2020. PMID: 33007266 Free PMC article.
GPCR activation mechanisms across classes and macro/microscales.
Hauser AS, Kooistra AJ, Munk C, Heydenreich FM, Veprintsev DB, Bouvier M, Babu MM, Gloriam DE. Hauser AS, et al. Among authors: babu mm. Nat Struct Mol Biol. 2021 Nov;28(11):879-888. doi: 10.1038/s41594-021-00674-7. Epub 2021 Nov 10. Nat Struct Mol Biol. 2021. PMID: 34759375 Free PMC article.
189 results