Kilford P - Search Results

1

Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters.

Achour B, Al-Majdoub ZM, Grybos-Gajniak A, Lea K, Kilford P, Zhang M, Knight D, Barber J, Schageman J, Rostami-Hodjegan A. Achour B, et al. Among authors: kilford p. Clin Pharmacol Ther. 2021 Jan;109(1):222-232. doi: 10.1002/cpt.2102. Epub 2020 Nov 25. Clin Pharmacol Ther. 2021. PMID: 33141922 Free PMC article.

2

Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework.

Zhang M, Fisher C, Gardner I, Pan X, Kilford P, Bois FY, Jamei M. Zhang M, et al. Among authors: kilford p. Drug Metab Dispos. 2022 Jul;50(7):957-967. doi: 10.1124/dmd.121.000818. Epub 2022 May 3. Drug Metab Dispos. 2022. PMID: 35504655

3

Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator.

Kilford PJ, Chen KF, Crewe K, Gardner I, Hatley O, Ke AB, Neuhoff S, Zhang M, Rowland Yeo K. Kilford PJ, et al. CPT Pharmacometrics Syst Pharmacol. 2022 Jul;11(7):822-832. doi: 10.1002/psp4.12794. Epub 2022 Apr 28. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35445542 Free PMC article.

4

A Mechanistic Absorption and Disposition Model of Ritonavir to Predict Exposure and Drug-Drug Interaction Potential of CYP3A4/5 and CYP2D6 Substrates.

Arora S, Pansari A, Kilford PJ, Jamei M, Turner DB, Gardner I. Arora S, et al. Among authors: kilford pj. Eur J Drug Metab Pharmacokinet. 2022 Jul;47(4):483-495. doi: 10.1007/s13318-022-00765-w. Epub 2022 Apr 29. Eur J Drug Metab Pharmacokinet. 2022. PMID: 35486324

5

Physiologically-Based Pharmacokinetic Models of CYP2D6 Substrate and Inhibitors Nebivolol, Cinacalcet and Mirabegron to Simulate Drug-Drug Interactions.

Kilford P, Khoshaein N, Southall R, Gardner I. Kilford P, et al. Eur J Drug Metab Pharmacokinet. 2022 Sep;47(5):699-710. doi: 10.1007/s13318-022-00775-8. Epub 2022 Jul 15. Eur J Drug Metab Pharmacokinet. 2022. PMID: 35840839

6

Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models.

Gardner I, Xu M, Han C, Wang Y, Jiao X, Jamei M, Khalidi H, Kilford P, Neuhoff S, Southall R, Turner DB, Musther H, Jones B, Taylor S. Gardner I, et al. Among authors: kilford p. Xenobiotica. 2022 Aug;52(8):943-956. doi: 10.1080/00498254.2022.2132426. Xenobiotica. 2022. PMID: 36222269

7

Biopharmaceutic In Vitro In Vivo Extrapolation (IVIV_E) Informed Physiologically-Based Pharmacokinetic Model of Ritonavir Norvir Tablet Absorption in Humans Under Fasted and Fed State Conditions.

Arora S, Pansari A, Kilford P, Jamei M, Gardner I, Turner DB. Arora S, et al. Among authors: kilford p. Mol Pharm. 2020 Jul 6;17(7):2329-2344. doi: 10.1021/acs.molpharmaceut.0c00043. Epub 2020 Jun 1. Mol Pharm. 2020. PMID: 32427480

8

Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations.

Gertz M, Kilford PJ, Houston JB, Galetin A. Gertz M, et al. Drug Metab Dispos. 2008 Mar;36(3):535-42. doi: 10.1124/dmd.107.018713. Epub 2007 Dec 20. Drug Metab Dispos. 2008. PMID: 18096674

9

Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes.

Kilford PJ, Stringer R, Sohal B, Houston JB, Galetin A. Kilford PJ, et al. Drug Metab Dispos. 2009 Jan;37(1):82-9. doi: 10.1124/dmd.108.023853. Epub 2008 Oct 2. Drug Metab Dispos. 2009. PMID: 18832476

10

Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data.

Kilford PJ, Gertz M, Houston JB, Galetin A. Kilford PJ, et al. Drug Metab Dispos. 2008 Jul;36(7):1194-7. doi: 10.1124/dmd.108.020834. Epub 2008 Apr 14. Drug Metab Dispos. 2008. PMID: 18411401

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