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Brain pathology and cerebellar purkinje cell loss in a mouse model of chronic neuronopathic Gaucher disease.
Pewzner-Jung Y, Joseph T, Blumenreich S, Vardi A, Ferreira NS, Cho SM, Eilam R, Tsoory M, Biton IE, Brumfeld V, Haffner-Krausz R, Brenner O, Sharabi N, Addadi Y, Salame TM, Rotkopf R, Wigoda N, Yayon N, Merrill AH Jr, Schiffmann R, Futerman AH. Pewzner-Jung Y, et al. Prog Neurobiol. 2021 Feb;197:101939. doi: 10.1016/j.pneurobio.2020.101939. Epub 2020 Nov 3. Prog Neurobiol. 2021. PMID: 33152398
Caspase-8 serves both apoptotic and nonapoptotic roles.
Kang TB, Ben-Moshe T, Varfolomeev EE, Pewzner-Jung Y, Yogev N, Jurewicz A, Waisman A, Brenner O, Haffner R, Gustafsson E, Ramakrishnan P, Lapidot T, Wallach D. Kang TB, et al. J Immunol. 2004 Sep 1;173(5):2976-84. doi: 10.4049/jimmunol.173.5.2976. J Immunol. 2004. PMID: 15322156
Ceramide synthase 1 is regulated by proteasomal mediated turnover.
Sridevi P, Alexander H, Laviad EL, Pewzner-Jung Y, Hannink M, Futerman AH, Alexander S. Sridevi P, et al. Biochim Biophys Acta. 2009 Jul;1793(7):1218-27. doi: 10.1016/j.bbamcr.2009.04.006. Epub 2009 Apr 22. Biochim Biophys Acta. 2009. PMID: 19393694 Free PMC article.
A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy.
Pewzner-Jung Y, Brenner O, Braun S, Laviad EL, Ben-Dor S, Feldmesser E, Horn-Saban S, Amann-Zalcenstein D, Raanan C, Berkutzki T, Erez-Roman R, Ben-David O, Levy M, Holzman D, Park H, Nyska A, Merrill AH Jr, Futerman AH. Pewzner-Jung Y, et al. J Biol Chem. 2010 Apr 2;285(14):10911-23. doi: 10.1074/jbc.M109.077610. Epub 2010 Jan 28. J Biol Chem. 2010. PMID: 20110366 Free PMC article.
Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels.
Ben-David O, Pewzner-Jung Y, Brenner O, Laviad EL, Kogot-Levin A, Weissberg I, Biton IE, Pienik R, Wang E, Kelly S, Alroy J, Raas-Rothschild A, Friedman A, Brügger B, Merrill AH Jr, Futerman AH. Ben-David O, et al. J Biol Chem. 2011 Aug 26;286(34):30022-33. doi: 10.1074/jbc.M111.261206. Epub 2011 Jun 24. J Biol Chem. 2011. PMID: 21705317 Free PMC article.
46 results