Johns DG - Search Results

1

Cholesteryl ester transfer protein (CETP) inhibitors based on cyclic urea, bicyclic urea and bicyclic sulfamide cores.

Liu J, Shao PP, Guiadeen D, Krikorian A, Sun W, Deng Q, Cumiskey AM, Duffy RA, Murphy BA, Mitra K, Johns DG, Duffy JL, Vachal P. Liu J, et al. Among authors: johns dg. Bioorg Med Chem Lett. 2021 Jan 15;32:127668. doi: 10.1016/j.bmcl.2020.127668. Epub 2020 Nov 6. Bioorg Med Chem Lett. 2021. PMID: 33161125

2

On- and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of cholesteryl ester-transfer protein (CETP) inhibitors.

Johns DG, Duffy J, Fisher T, Hubbard BK, Forrest MJ. Johns DG, et al. Drugs. 2012 Mar 5;72(4):491-507. doi: 10.2165/11599310-000000000-00000. Drugs. 2012. PMID: 22356288 Review.

3

Inhibition of cholesteryl ester transfer protein by anacetrapib does not impair the anti-inflammatory properties of high density lipoprotein.

Han S, Levoci L, Fischer P, Wang SP, Gagen K, Chen Y, Xie D, Fisher T, Ehrhardt AG, Peier AM, Johns DG. Han S, et al. Among authors: johns dg. Biochim Biophys Acta. 2013 Apr;1831(4):825-33. doi: 10.1016/j.bbalip.2012.12.008. Epub 2012 Dec 23. Biochim Biophys Acta. 2013. PMID: 23269286

4

Use of [13C18] oleic acid and mass isotopomer distribution analysis to study synthesis of plasma triglycerides in vivo: analytical and experimental considerations.

McLaren DG, Cardasis HL, Stout SJ, Wang SP, Mendoza V, Castro-Perez JM, Miller PL, Murphy BA, Cumiskey AM, Cleary MA, Johns DG, Previs SF, Roddy TP. McLaren DG, et al. Among authors: johns dg. Anal Chem. 2013 Jul 2;85(13):6287-94. doi: 10.1021/ac400363k. Epub 2013 Jun 10. Anal Chem. 2013. PMID: 23668715

5

In vivo effects of anacetrapib on preβ HDL: improvement in HDL remodeling without effects on cholesterol absorption.

Wang SP, Daniels E, Chen Y, Castro-Perez J, Zhou H, Akinsanya KO, Previs SF, Roddy TP, Johns DG. Wang SP, et al. Among authors: johns dg. J Lipid Res. 2013 Oct;54(10):2858-65. doi: 10.1194/jlr.M041541. Epub 2013 Jul 29. J Lipid Res. 2013. PMID: 23898048 Free PMC article.

6

Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques.

Roddy TP, McLaren DG, Chen Y, Xie D, Dunn K, Kulick A, Szeto D, Forrest G, Albanese K, Donnelly M, Gai C, Gewain A, Lederman H, Jensen KK, Ai X, Vachal P, Akinsanya KO, Cleary MA, Previs SF, Dansky HM, Johns DG. Roddy TP, et al. Among authors: johns dg. Eur J Pharmacol. 2014 Oct 5;740:410-6. doi: 10.1016/j.ejphar.2014.04.015. Epub 2014 Apr 21. Eur J Pharmacol. 2014. PMID: 24769414

7

Cholesteryl ester transfer protein inhibition enhances endothelial repair and improves endothelial function in the rabbit.

Wu BJ, Shrestha S, Ong KL, Johns D, Hou L, Barter PJ, Rye KA. Wu BJ, et al. Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):628-36. doi: 10.1161/ATVBAHA.114.304747. Epub 2015 Jan 29. Arterioscler Thromb Vasc Biol. 2015. PMID: 25633313

8

Inhibition of cholesteryl ester transfer protein increases cholesteryl ester content of large HDL independently of HDL-to-HDL homotypic transfer: in vitro vs in vivo comparison using anacetrapib and dalcetrapib.

Johns DG, Chen Y, Wang SP, Castro-Perez J, Previs SF, Roddy TP. Johns DG, et al. Eur J Pharmacol. 2015 Sep 5;762:256-62. doi: 10.1016/j.ejphar.2015.05.061. Epub 2015 Jun 3. Eur J Pharmacol. 2015. PMID: 26049012

9

Increasing HDL levels by inhibiting cholesteryl ester transfer protein activity in rabbits with hindlimb ischemia is associated with increased angiogenesis.

Wu BJ, Shrestha S, Ong KL, Johns D, Dunn LL, Hou L, Barter PJ, Rye KA. Wu BJ, et al. Int J Cardiol. 2015 Nov 15;199:204-12. doi: 10.1016/j.ijcard.2015.07.014. Epub 2015 Jul 11. Int J Cardiol. 2015. PMID: 26204569

10

Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux.

McLaren DG, Previs SF, Phair RD, Stout SJ, Xie D, Chen Y, Salituro GM, Xu SS, Castro-Perez JM, Opiteck GJ, Akinsanya KO, Cleary MA, Dansky HM, Johns DG, Roddy TP. McLaren DG, et al. Among authors: johns dg. J Lipid Res. 2016 Mar;57(3):398-409. doi: 10.1194/jlr.M063842. Epub 2015 Dec 9. J Lipid Res. 2016. PMID: 26658238 Free PMC article.

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