Seyb K - Search Results

1

Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.

Alleyne C, Amin RP, Bhatt B, Bianchi E, Blain JC, Boyer N, Branca D, Embrey MW, Ha SN, Jette K, Johns DG, Kerekes AD, Koeplinger KA, LaPlaca D, Li N, Murphy B, Orth P, Ricardo A, Salowe S, Seyb K, Shahripour A, Stringer JR, Sun Y, Tracy R, Wu C, Xiong Y, Youm H, Zokian HJ, Tucker TJ. Alleyne C, et al. Among authors: seyb k. J Med Chem. 2020 Nov 25;63(22):13796-13824. doi: 10.1021/acs.jmedchem.0c01084. Epub 2020 Nov 10. J Med Chem. 2020. PMID: 33170686

2

Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors.

Qiao L, Choi S, Case A, Gainer TG, Seyb K, Glicksman MA, Lo DC, Stein RL, Cuny GD. Qiao L, et al. Among authors: seyb k. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6122-6. doi: 10.1016/j.bmcl.2009.09.010. Epub 2009 Sep 9. Bioorg Med Chem Lett. 2009. PMID: 19783434 Free PMC article.

3

Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2--discovery of LRRK2 inhibitors.

Liu M, Poulose S, Schuman E, Zaitsev AD, Dobson B, Auerbach K, Seyb K, Cuny GD, Glicksman MA, Stein RL, Yue Z. Liu M, et al. Among authors: seyb k. Anal Biochem. 2010 Sep 15;404(2):186-92. doi: 10.1016/j.ab.2010.05.033. Epub 2010 Jun 2. Anal Biochem. 2010. PMID: 20566370 Free PMC article.

4

Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors.

Pytel D, Seyb K, Liu M, Ray SS, Concannon J, Huang M, Cuny GD, Diehl JA, Glicksman MA. Pytel D, et al. Among authors: seyb k. J Biomol Screen. 2014 Aug;19(7):1024-34. doi: 10.1177/1087057114525853. Epub 2014 Mar 5. J Biomol Screen. 2014. PMID: 24598103 Free PMC article.

5

Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis.

Manocha GD, Puig KL, Austin SA, Seyb K, Glicksman MA, Combs CK. Manocha GD, et al. Among authors: seyb k. PLoS One. 2015 Jul 10;10(7):e0132604. doi: 10.1371/journal.pone.0132604. eCollection 2015. PLoS One. 2015. PMID: 26161952 Free PMC article.

6

Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease.

Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, Greengard P, Lam TT, Tautz L, Nairn AC, Ellman JA, Lombroso PJ. Xu J, et al. Among authors: seyb k. PLoS Biol. 2014 Aug 5;12(8):e1001923. doi: 10.1371/journal.pbio.1001923. eCollection 2014 Aug. PLoS Biol. 2014. PMID: 25093460 Free PMC article.

7

Inhibition of large T antigen ATPase activity as a potential strategy to develop anti-polyomavirus JC drugs.

Randhawa P, Zeng G, Bueno M, Salgarkar A, Lesniak A, Isse K, Seyb K, Perry A, Charles I, Hustus C, Huang M, Smith M, Glicksman MA. Randhawa P, et al. Among authors: seyb k. Antiviral Res. 2014 Dec;112:113-9. doi: 10.1016/j.antiviral.2014.10.004. Epub 2014 Oct 15. Antiviral Res. 2014. PMID: 25453344 Free PMC article.

8

Identification of small molecule inhibitors of beta-amyloid cytotoxicity through a cell-based high-throughput screening platform.

Seyb KI, Schuman ER, Ni J, Huang MM, Michaelis ML, Glicksman MA. Seyb KI, et al. J Biomol Screen. 2008 Oct;13(9):870-8. doi: 10.1177/1087057108323909. Epub 2008 Sep 23. J Biomol Screen. 2008. PMID: 18812568 Free PMC article.

9

Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation.

Yang Z, Concannon J, Ng KS, Seyb K, Mortensen LJ, Ranganath S, Gu F, Levy O, Tong Z, Martyn K, Zhao W, Lin CP, Glicksman MA, Karp JM. Yang Z, et al. Among authors: seyb k. Sci Rep. 2016 Jul 26;6:30263. doi: 10.1038/srep30263. Sci Rep. 2016. PMID: 27457881 Free PMC article.

10

Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization.

So PP, Zeldich E, Seyb KI, Huang MM, Concannon JB, King GD, Chen CD, Cuny GD, Glicksman MA, Abraham CR. So PP, et al. Among authors: seyb ki. Am J Neurodegener Dis. 2012;1(1):75-87. Am J Neurodegener Dis. 2012. PMID: 22822474 Free PMC article.

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