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The aurora kinases in cell cycle and leukemia.
Goldenson B, Crispino JD. Goldenson B, et al. Oncogene. 2015 Jan 29;34(5):537-45. doi: 10.1038/onc.2014.14. Epub 2014 Mar 17. Oncogene. 2015. PMID: 24632603 Free PMC article. Review.
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Goldberg L, Birger Y, Izraeli S, Gamis AS, Smith FO, Woods WG, Taub J, Scherer CA, Bradner JE, Goh BC, Mercher T, Carpenter AE, Gould RJ, Clemons PA, Carr SA, Root DE, Schreiber SL, Stern AM, Crispino JD. Wen Q, et al. Cell. 2012 Aug 3;150(3):575-89. doi: 10.1016/j.cell.2012.06.032. Cell. 2012. PMID: 22863010 Free PMC article.
Normal and malignant megakaryopoiesis.
Wen Q, Goldenson B, Crispino JD. Wen Q, et al. Expert Rev Mol Med. 2011 Oct 21;13:e32. doi: 10.1017/S1462399411002043. Expert Rev Mol Med. 2011. PMID: 22018018 Free PMC article. Review.
AKT is a therapeutic target in myeloproliferative neoplasms.
Khan I, Huang Z, Wen Q, Stankiewicz MJ, Gilles L, Goldenson B, Schultz R, Diebold L, Gurbuxani S, Finke CM, Lasho TL, Koppikar P, Pardanani A, Stein B, Altman JK, Levine RL, Tefferi A, Crispino JD. Khan I, et al. Leukemia. 2013 Sep;27(9):1882-90. doi: 10.1038/leu.2013.167. Epub 2013 Jun 10. Leukemia. 2013. PMID: 23748344 Free PMC article.
Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.
Wen QJ, Yang Q, Goldenson B, Malinge S, Lasho T, Schneider RK, Breyfogle LJ, Schultz R, Gilles L, Koppikar P, Abdel-Wahab O, Pardanani A, Stein B, Gurbuxani S, Mullally A, Levine RL, Tefferi A, Crispino JD. Wen QJ, et al. Nat Med. 2015 Dec;21(12):1473-80. doi: 10.1038/nm.3995. Epub 2015 Nov 16. Nat Med. 2015. PMID: 26569382 Free PMC article.
13 results