Zwart EP - Search Results

1

Mutagenicity of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in human TP53 knock-in (Hupki) mouse embryo fibroblasts.

Hölzl-Armstrong L, Moody S, Kucab JE, Zwart EP, Bellamri M, Luijten M, Turesky RJ, Stratton MR, Arlt VM, Phillips DH. Hölzl-Armstrong L, et al. Among authors: zwart ep. Food Chem Toxicol. 2021 Jan;147:111855. doi: 10.1016/j.fct.2020.111855. Epub 2020 Nov 12. Food Chem Toxicol. 2021. PMID: 33189884

2

Proliferating primary hepatocytes from the pUR288 lacZ plasmid mouse are valuable tools for genotoxicity assessment in vitro.

Zwart EP, Schaap MM, van den Dungen MW, Braakhuis HM, White PA, van Steeg H, van Benthem J, Luijten M. Zwart EP, et al. Environ Mol Mutagen. 2012 Jun;53(5):1-8. doi: 10.1002/em.21700. Epub 2012 May 23. Environ Mol Mutagen. 2012. PMID: 22619112

3

Dissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes.

Schaap MM, Zwart EP, Wackers PF, Huijskens I, van de Water B, Breit TM, van Steeg H, Jonker MJ, Luijten M. Schaap MM, et al. Among authors: zwart ep. Arch Toxicol. 2012 Nov;86(11):1717-27. doi: 10.1007/s00204-012-0883-6. Epub 2012 Jun 19. Arch Toxicol. 2012. PMID: 22710402

4

Slow accumulation of mutations in Xpc-/- mice upon induction of oxidative stress.

Melis JP, Kuiper RV, Zwart E, Robinson J, Pennings JL, van Oostrom CT, Luijten M, van Steeg H. Melis JP, et al. DNA Repair (Amst). 2013 Dec;12(12):1081-6. doi: 10.1016/j.dnarep.2013.08.019. Epub 2013 Sep 29. DNA Repair (Amst). 2013. PMID: 24084170 Free PMC article.

5

In vivo murine hepatic microRNA and mRNA expression signatures predicting the (non-)genotoxic carcinogenic potential of chemicals.

Melis JP, Derks KW, Pronk TE, Wackers P, Schaap MM, Zwart E, van Ijcken WF, Jonker MJ, Breit TM, Pothof J, van Steeg H, Luijten M. Melis JP, et al. Arch Toxicol. 2014 Apr;88(4):1023-34. doi: 10.1007/s00204-013-1189-z. Epub 2014 Jan 5. Arch Toxicol. 2014. PMID: 24390151

6

A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.

Schaap MM, Wackers PF, Zwart EP, Huijskens I, Jonker MJ, Hendriks G, Breit TM, van Steeg H, van de Water B, Luijten M. Schaap MM, et al. Among authors: zwart ep. Arch Toxicol. 2015 Dec;89(12):2413-27. doi: 10.1007/s00204-014-1368-6. Epub 2014 Oct 2. Arch Toxicol. 2015. PMID: 25270620

7

TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts.

Kucab JE, Zwart EP, van Steeg H, Luijten M, Schmeiser HH, Phillips DH, Arlt VM. Kucab JE, et al. Among authors: zwart ep. DNA Repair (Amst). 2016 Mar;39:21-33. doi: 10.1016/j.dnarep.2015.11.004. Epub 2015 Dec 8. DNA Repair (Amst). 2016. PMID: 26723900 Free PMC article.

8

Evaluation of the LacZ reporter assay in cryopreserved primary hepatocytes for In vitro genotoxicity testing.

Luijten M, Zwart EP, Dollé ME, de Pooter M, Cox JA, White PA, van Benthem J. Luijten M, et al. Among authors: zwart ep. Environ Mol Mutagen. 2016 Dec;57(9):643-655. doi: 10.1002/em.22063. Epub 2016 Nov 9. Environ Mol Mutagen. 2016. PMID: 27859631

9

Is current risk assessment of non-genotoxic carcinogens protective?

Braakhuis HM, Slob W, Olthof ED, Wolterink G, Zwart EP, Gremmer ER, Rorije E, van Benthem J, Woutersen R, van der Laan JW, Luijten M. Braakhuis HM, et al. Among authors: zwart ep. Crit Rev Toxicol. 2018 Jul;48(6):500-511. doi: 10.1080/10408444.2018.1458818. Epub 2018 May 10. Crit Rev Toxicol. 2018. PMID: 29745287 Review.

10

The development and prevalidation of an in vitro mutagenicity assay based on MutaMouse primary hepatocytes, Part I: Isolation, structural, genetic, and biochemical characterization.

Cox JA, Zwart EP, Luijten M, White PA. Cox JA, et al. Among authors: zwart ep. Environ Mol Mutagen. 2019 May;60(4):331-347. doi: 10.1002/em.22253. Epub 2018 Dec 27. Environ Mol Mutagen. 2019. PMID: 30592088 Free PMC article.

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