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From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement.
Mostinski Y, Heynen GJJE, López-Alberca MP, Paul J, Miksche S, Radetzki S, Schaller D, Shanina E, Seyffarth C, Kolomeets Y, Ziebart N, de Schryver J, Oestreich S, Neuenschwander M, Roske Y, Heinemann U, Rademacher C, Volkamer A, von Kries JP, Birchmeier W, Nazaré M. Mostinski Y, et al. Among authors: rademacher c. J Med Chem. 2020 Dec 10;63(23):14780-14804. doi: 10.1021/acs.jmedchem.0c01265. Epub 2020 Nov 19. J Med Chem. 2020. PMID: 33210922
Chemical fragment arrays for rapid druggability assessment.
Aretz J, Kondoh Y, Honda K, Anumala UR, Nazaré M, Watanabe N, Osada H, Rademacher C. Aretz J, et al. Among authors: rademacher c. Chem Commun (Camb). 2016 Jul 12;52(58):9067-70. doi: 10.1039/c5cc10457b. Chem Commun (Camb). 2016. PMID: 26890187
Discovery of BAZ2A bromodomain ligands.
Spiliotopoulos D, Wamhoff EC, Lolli G, Rademacher C, Caflisch A. Spiliotopoulos D, et al. Among authors: rademacher c. Eur J Med Chem. 2017 Oct 20;139:564-572. doi: 10.1016/j.ejmech.2017.08.028. Epub 2017 Aug 12. Eur J Med Chem. 2017. PMID: 28837921
Allosteric Inhibition of a Mammalian Lectin.
Aretz J, Anumala UR, Fuchsberger FF, Molavi N, Ziebart N, Zhang H, Nazaré M, Rademacher C. Aretz J, et al. Among authors: rademacher c. J Am Chem Soc. 2018 Nov 7;140(44):14915-14925. doi: 10.1021/jacs.8b08644. Epub 2018 Oct 24. J Am Chem Soc. 2018. PMID: 30303367
CellFy: A Cell-Based Fragment Screen against C-Type Lectins.
Schulze J, Baukmann H, Wawrzinek R, Fuchsberger FF, Specker E, Aretz J, Nazaré M, Rademacher C. Schulze J, et al. Among authors: rademacher c. ACS Chem Biol. 2018 Dec 21;13(12):3229-3235. doi: 10.1021/acschembio.8b00875. Epub 2018 Dec 3. ACS Chem Biol. 2018. PMID: 30480432
The 3F Library: Fluorinated Fsp3 -Rich Fragments for Expeditious 19 F NMR Based Screening.
Troelsen NS, Shanina E, Gonzalez-Romero D, Danková D, Jensen ISA, Śniady KJ, Nami F, Zhang H, Rademacher C, Cuenda A, Gotfredsen CH, Clausen MH. Troelsen NS, et al. Among authors: rademacher c. Angew Chem Int Ed Engl. 2020 Feb 3;59(6):2204-2210. doi: 10.1002/anie.201913125. Epub 2019 Dec 17. Angew Chem Int Ed Engl. 2020. PMID: 31724281
Protein-observed 19F NMR of LecA from Pseudomonas aeruginosa.
Shanina E, Siebs E, Zhang H, Varón Silva D, Joachim I, Titz A, Rademacher C. Shanina E, et al. Among authors: rademacher c. Glycobiology. 2021 Feb 9;31(2):159-165. doi: 10.1093/glycob/cwaa057. Glycobiology. 2021. PMID: 32573695 Free PMC article.
154 results