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From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement.
J Med Chem. 2020 Dec 10;63(23):14780-14804. doi: 10.1021/acs.jmedchem.0c01265. Epub 2020 Nov 19.
J Med Chem. 2020.
PMID: 33210922
Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A.
Schröder D, Rehbach C, Seyffarth C, Neuenschwander M, Kries JV, Windhorst S.
Schröder D, et al. Among authors: seyffarth c.
Biochem Biophys Res Commun. 2013 Sep 20;439(2):228-34. doi: 10.1016/j.bbrc.2013.08.053. Epub 2013 Aug 24.
Biochem Biophys Res Commun. 2013.
PMID: 23981806
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Small Molecules Targeting Human UDP-GlcNAc 2-Epimerase.
Gorenflos López JL, Dornan GL, Boback N, Neuenschwander M, Oder A, Kemnitz-Hassanin K, Schmieder P, Specker E, Asikoglu HC, Oberdanner C, Seyffarth C, von Kries JP, Lauster D, Hinderlich S, Hackenberger CPR.
Gorenflos López JL, et al. Among authors: seyffarth c.
Chembiochem. 2023 Dec 14;24(24):e202300555. doi: 10.1002/cbic.202300555. Epub 2023 Oct 16.
Chembiochem. 2023.
PMID: 37769151
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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.
Aguirre T, Dornan GL, Hostachy S, Neuenschwander M, Seyffarth C, Haucke V, Schütz A, von Kries JP, Fiedler D.
Aguirre T, et al. Among authors: seyffarth c.
Elife. 2023 Oct 16;12:RP88982. doi: 10.7554/eLife.88982.
Elife. 2023.
PMID: 37843983
Free PMC article.
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Activity-related energy expenditure in older adults: a call for more research.
Hall KS, Morey MC, Dutta C, Manini TM, Weltman AL, Nelson ME, Morgan AL, Senior JG, Seyffarth C, Buchner DM.
Hall KS, et al. Among authors: seyffarth c.
Med Sci Sports Exerc. 2014 Dec;46(12):2335-40. doi: 10.1249/MSS.0000000000000356.
Med Sci Sports Exerc. 2014.
PMID: 24714651
Free PMC article.
Review.
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