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Mechanisms of a Sustained Anti-inflammatory Drug Response in Alveolar Macrophages Unraveled with Mathematical Modeling.
CPT Pharmacometrics Syst Pharmacol. 2020 Dec;9(12):707-717. doi: 10.1002/psp4.12568. Epub 2020 Dec 13.
CPT Pharmacometrics Syst Pharmacol. 2020.
PMID: 33217190
Free PMC article.
Mathematical modeling improves EC50 estimations from classical dose-response curves.
Nyman E, Lindgren I, Lövfors W, Lundengård K, Cervin I, Sjöström TA, Altimiras J, Cedersund G.
Nyman E, et al. Among authors: lovfors w.
FEBS J. 2015 Mar;282(5):951-62. doi: 10.1111/febs.13194. Epub 2015 Feb 6.
FEBS J. 2015.
PMID: 25586512
Free article.
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LASSIM-A network inference toolbox for genome-wide mechanistic modeling.
Magnusson R, Mariotti GP, Köpsén M, Lövfors W, Gawel DR, Jörnsten R, Linde J, Nordling TEM, Nyman E, Schulze S, Nestor CE, Zhang H, Cedersund G, Benson M, Tjärnberg A, Gustafsson M.
Magnusson R, et al. Among authors: lovfors w.
PLoS Comput Biol. 2017 Jun 22;13(6):e1005608. doi: 10.1371/journal.pcbi.1005608. eCollection 2017 Jun.
PLoS Comput Biol. 2017.
PMID: 28640810
Free PMC article.
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Mathematical modeling of white adipocyte exocytosis predicts adiponectin secretion and quantifies the rates of vesicle exo- and endocytosis.
Brännmark C, Lövfors W, Komai AM, Axelsson T, El Hachmane MF, Musovic S, Paul A, Nyman E, Olofsson CS.
Brännmark C, et al. Among authors: lovfors w.
J Biol Chem. 2017 Dec 8;292(49):20032-20043. doi: 10.1074/jbc.M117.801225. Epub 2017 Sep 25.
J Biol Chem. 2017.
PMID: 28972187
Free PMC article.
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A systems biology analysis of adrenergically stimulated adiponectin exocytosis in white adipocytes.
Lövfors W, Simonsson C, Komai AM, Nyman E, Olofsson CS, Cedersund G.
Lövfors W, et al.
J Biol Chem. 2021 Nov;297(5):101221. doi: 10.1016/j.jbc.2021.101221. Epub 2021 Sep 29.
J Biol Chem. 2021.
PMID: 34597667
Free PMC article.
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A systems biology analysis of lipolysis and fatty acid release from adipocytes in vitro and from adipose tissue in vivo.
Lövfors W, Ekström J, Jönsson C, Strålfors P, Cedersund G, Nyman E.
Lövfors W, et al.
PLoS One. 2021 Dec 31;16(12):e0261681. doi: 10.1371/journal.pone.0261681. eCollection 2021.
PLoS One. 2021.
PMID: 34972146
Free PMC article.
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A comprehensive mechanistic model of adipocyte signaling with layers of confidence.
Lövfors W, Magnusson R, Jönsson C, Gustafsson M, Olofsson CS, Cedersund G, Nyman E.
Lövfors W, et al.
NPJ Syst Biol Appl. 2023 Jun 7;9(1):24. doi: 10.1038/s41540-023-00282-9.
NPJ Syst Biol Appl. 2023.
PMID: 37286693
Free PMC article.
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A physiologically-based digital twin for alcohol consumption-predicting real-life drinking responses and long-term plasma PEth.
Podéus H, Simonsson C, Nasr P, Ekstedt M, Kechagias S, Lundberg P, Lövfors W, Cedersund G.
Podéus H, et al. Among authors: lovfors w.
NPJ Digit Med. 2024 May 3;7(1):112. doi: 10.1038/s41746-024-01089-6.
NPJ Digit Med. 2024.
PMID: 38702474
Free PMC article.
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