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TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression.
Dwyer BJ, Jarman EJ, Gogoi-Tiwari J, Ferreira-Gonzalez S, Boulter L, Guest RV, Kendall TJ, Kurian D, Kilpatrick AM, Robson AJ, O'Duibhir E, Man TY, Campana L, Starkey Lewis PJ, Wigmore SJ, Olynyk JK, Ramm GA, Tirnitz-Parker JEE, Forbes SJ. Dwyer BJ, et al. Among authors: guest rv. J Hepatol. 2021 Apr;74(4):860-872. doi: 10.1016/j.jhep.2020.11.018. Epub 2020 Nov 19. J Hepatol. 2021. PMID: 33221352 Free article.
Notch3 drives development and progression of cholangiocarcinoma.
Guest RV, Boulter L, Dwyer BJ, Kendall TJ, Man TY, Minnis-Lyons SE, Lu WY, Robson AJ, Gonzalez SF, Raven A, Wojtacha D, Morton JP, Komuta M, Roskams T, Wigmore SJ, Sansom OJ, Forbes SJ. Guest RV, et al. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12250-12255. doi: 10.1073/pnas.1600067113. Epub 2016 Oct 10. Proc Natl Acad Sci U S A. 2016. PMID: 27791012 Free PMC article.
Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation.
Minnis-Lyons SE, Ferreira-González S, Aleksieva N, Man TY, Gadd VL, Williams MJ, Guest RV, Lu WY, Dwyer BJ, Jamieson T, Nixon C, Van Hul N, Lemaigre FP, McCafferty J, Leclercq IA, Sansom OJ, Boulter L, Forbes SJ. Minnis-Lyons SE, et al. Among authors: guest rv. Sci Signal. 2021 Jun 22;14(688):eaay9185. doi: 10.1126/scisignal.aay9185. Sci Signal. 2021. PMID: 34158399
In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma.
Younger NT, Wilson ML, Martinez Lyons A, Jarman EJ, Meynert AM, Grimes GR, Gournopanos K, Waddell SH, Tennant PA, Wilson DH, Guest RV, Wigmore SJ, Acosta JC, Kendall TJ, Taylor MS, Sproul D, Mill P, Boulter L. Younger NT, et al. Among authors: guest rv. Cancer Res. 2022 Apr 15;82(8):1548-1559. doi: 10.1158/0008-5472.CAN-21-2556. Cancer Res. 2022. PMID: 35074757 Free PMC article.
Polysialic acid/neural cell adhesion molecule modulates the formation of ductular reactions in liver injury.
Tsuchiya A, Lu WY, Weinhold B, Boulter L, Stutchfield BM, Williams MJ, Guest RV, Minnis-Lyons SE, MacKinnon AC, Schwarzer D, Ichida T, Nomoto M, Aoyagi Y, Gerardy-Schahn R, Forbes SJ. Tsuchiya A, et al. Among authors: guest rv. Hepatology. 2014 Nov;60(5):1727-40. doi: 10.1002/hep.27099. Epub 2014 Sep 29. Hepatology. 2014. PMID: 24585441 Free article.
Modulation of Biliary Cancer Chemo-Resistance Through MicroRNA-Mediated Rewiring of the Expansion of CD133+ Cells.
Carotenuto P, Hedayat S, Fassan M, Cardinale V, Lampis A, Guzzardo V, Vicentini C, Scarpa A, Cascione L, Costantini D, Carpino G, Alvaro D, Ghidini M, Trevisani F, Te Poele R, Salati M, Ventura S, Vlachogiannis G, Hahne JC, Boulter L, Forbes SJ, Guest RV, Cillo U, Said-Huntingford I, Begum R, Smyth E, Michalarea V, Cunningham D, Rimassa L, Santoro A, Roncalli M, Kirkin V, Clarke P, Workman P, Valeri N, Braconi C. Carotenuto P, et al. Among authors: guest rv. Hepatology. 2020 Sep;72(3):982-996. doi: 10.1002/hep.31094. Epub 2020 Sep 10. Hepatology. 2020. PMID: 31879968 Free PMC article.
WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.
Boulter L, Guest RV, Kendall TJ, Wilson DH, Wojtacha D, Robson AJ, Ridgway RA, Samuel K, Van Rooijen N, Barry ST, Wigmore SJ, Sansom OJ, Forbes SJ. Boulter L, et al. Among authors: guest rv. J Clin Invest. 2015 Mar 2;125(3):1269-85. doi: 10.1172/JCI76452. Epub 2015 Feb 17. J Clin Invest. 2015. PMID: 25689248 Free PMC article.
24 results