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Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.
Yeung J, Apopa PL, Vesci J, Kenyon V, Rai G, Jadhav A, Simeonov A, Holman TR, Maloney DJ, Boutaud O, Holinstat M. Yeung J, et al. Among authors: holman tr. Mol Pharmacol. 2012 Mar;81(3):420-30. doi: 10.1124/mol.111.075630. Epub 2011 Dec 9. Mol Pharmacol. 2012. PMID: 22155783 Free PMC article.
Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation.
Yeung J, Tourdot BE, Fernandez-Perez P, Vesci J, Ren J, Smyrniotis CJ, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, McKenzie SE, Holinstat M. Yeung J, et al. Among authors: holman tr. Blood. 2014 Oct 2;124(14):2271-9. doi: 10.1182/blood-2014-05-575878. Epub 2014 Aug 6. Blood. 2014. PMID: 25100742 Free PMC article.
A potent and selective inhibitor targeting human and murine 12/15-LOX.
Armstrong MM, Freedman CJ, Jung JE, Zheng Y, Kalyanaraman C, Jacobson MP, Simeonov A, Maloney DJ, van Leyen K, Jadhav A, Holman TR. Armstrong MM, et al. Among authors: holman tr. Bioorg Med Chem. 2016 Mar 15;24(6):1183-90. doi: 10.1016/j.bmc.2016.01.042. Epub 2016 Jan 21. Bioorg Med Chem. 2016. PMID: 26899595 Free PMC article.
Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase.
Deschamps JD, Ogunsola AF, Jameson JB 2nd, Yasgar A, Flitter BA, Freedman CJ, Melvin JA, Nguyen JV, Maloney DJ, Jadhav A, Simeonov A, Bomberger JM, Holman TR. Deschamps JD, et al. Among authors: holman tr. Biochemistry. 2016 Jun 14;55(23):3329-40. doi: 10.1021/acs.biochem.6b00338. Epub 2016 Jun 3. Biochemistry. 2016. PMID: 27226387 Free PMC article.
First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.
Adili R, Tourdot BE, Mast K, Yeung J, Freedman JC, Green A, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, Holinstat M. Adili R, et al. Among authors: holman tr. Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1828-1839. doi: 10.1161/ATVBAHA.117.309868. Epub 2017 Aug 3. Arterioscler Thromb Vasc Biol. 2017. PMID: 28775075 Free PMC article.
108 results