Wesolowski GA - Search Results

1

Preclinical evaluation of [¹¹ C]L-235 as a radioligand for Positron Emission Tomography cathepsin K imaging in bone.

Bennacef I, Rubins D, Riffel K, Williams M, Posavec DJ, Holahan MA, Purcell ML, Haley HD, Wolf M, Stachel SJ, Lubbers LS, Wesolowski GA, Duong LT, Hamill TG, Evelhoch JL, Hostetler ED. Bennacef I, et al. Among authors: wesolowski ga. J Labelled Comp Radiopharm. 2021 Apr;64(4):159-167. doi: 10.1002/jlcr.3896. Epub 2020 Dec 2. J Labelled Comp Radiopharm. 2021. PMID: 33226657

2

Applicability of in vitro-in vivo translation of cathepsin K inhibition from animal species to human with the use of free-drug hypothesis.

Ma B, Luo B, Euler DH, Cusick TE, Wesolowski G, Glantschnig H, Duong LT, Ou Y, Carroll SS, Lubbers LS. Ma B, et al. Naunyn Schmiedebergs Arch Pharmacol. 2017 Apr;390(4):435-441. doi: 10.1007/s00210-017-1356-5. Epub 2017 Feb 20. Naunyn Schmiedebergs Arch Pharmacol. 2017. PMID: 28220210 Clinical Trial.

3

Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis.

Ginnetti AT, Paone DV, Nanda KK, Li J, Busuek M, Johnson SA, Lu J, Soisson SM, Robinson R, Fisher J, Webber A, Wesolowski G, Ma B, Duong L, Carroll S, Burgey CS, Stachel SJ. Ginnetti AT, et al. Bioorg Med Chem Lett. 2022 Oct 15;74:128927. doi: 10.1016/j.bmcl.2022.128927. Epub 2022 Aug 6. Bioorg Med Chem Lett. 2022. PMID: 35944849

4

Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis.

Hayami T, Zhuo Y, Wesolowski GA, Pickarski M, Duong LT. Hayami T, et al. Among authors: wesolowski ga. Bone. 2012 Jun;50(6):1250-9. doi: 10.1016/j.bone.2012.03.025. Epub 2012 Mar 30. Bone. 2012. PMID: 22484689

5

Efficacy of a cathepsin K inhibitor in a preclinical model for prevention and treatment of breast cancer bone metastasis.

Duong LT, Wesolowski GA, Leung P, Oballa R, Pickarski M. Duong LT, et al. Among authors: wesolowski ga. Mol Cancer Ther. 2014 Dec;13(12):2898-909. doi: 10.1158/1535-7163.MCT-14-0253. Epub 2014 Sep 23. Mol Cancer Ther. 2014. PMID: 25249554

6

Suppression of cathepsin K biomarker in synovial fluid as a free-drug-driven process.

Ma B, Wesolowski G, Luo B, Lifsted T, Wessner K, Adamson G, Glantschnig H, Lubbers LS. Ma B, et al. J Circ Biomark. 2019 Jan 7;8:1849454418821819. doi: 10.1177/1849454418821819. eCollection 2019 Jan-Dec. J Circ Biomark. 2019. PMID: 30671145 Free PMC article.

7

Determination of in Vivo Enzyme Occupancy Utilizing Inhibitor Dissociation Kinetics.

Murphy DJ, Ou Y, Euler DH, Wessner K, Adamski S, Luo B, Wesolowski GA, Vogel R, Glantschnig H, Lubbers LS, Carroll SS, Lai MT. Murphy DJ, et al. Among authors: wesolowski ga. J Am Chem Soc. 2015 Sep 9;137(35):11230-3. doi: 10.1021/jacs.5b06518. Epub 2015 Aug 27. J Am Chem Soc. 2015. PMID: 26301491

8

Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys.

Masarachia PJ, Pennypacker BL, Pickarski M, Scott KR, Wesolowski GA, Smith SY, Samadfam R, Goetzmann JE, Scott BB, Kimmel DB, Duong LT. Masarachia PJ, et al. Among authors: wesolowski ga. J Bone Miner Res. 2012 Mar;27(3):509-23. doi: 10.1002/jbmr.1475. J Bone Miner Res. 2012. PMID: 22113859 Free article.

9

Nonpeptide alphavbeta3 antagonists. Part 11: discovery and preclinical evaluation of potent alphavbeta3 antagonists for the prevention and treatment of osteoporosis.

Coleman PJ, Brashear KM, Askew BC, Hutchinson JH, McVean CA, Duong LT, Feuston BP, Fernandez-Metzler C, Gentile MA, Hartman GD, Kimmel DB, Leu CT, Lipfert L, Merkle K, Pennypacker B, Prueksaritanont T, Rodan GA, Wesolowski GA, Rodan SB, Duggan ME. Coleman PJ, et al. Among authors: wesolowski ga. J Med Chem. 2004 Sep 23;47(20):4829-37. doi: 10.1021/jm049874c. J Med Chem. 2004. PMID: 15369386

10

M-CSF induces the stable interaction of cFms with alphaVbeta3 integrin in osteoclasts.

Elsegood CL, Zhuo Y, Wesolowski GA, Hamilton JA, Rodan GA, Duong LT. Elsegood CL, et al. Among authors: wesolowski ga. Int J Biochem Cell Biol. 2006;38(9):1518-29. doi: 10.1016/j.biocel.2006.02.011. Epub 2006 Mar 2. Int J Biochem Cell Biol. 2006. PMID: 16600665

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