Ito S - Search Results

1

Esaxerenone (CS-3150) in Patients with Type 2 Diabetes and Microalbuminuria (ESAX-DN): Phase 3 Randomized Controlled Clinical Trial.

Ito S, Kashihara N, Shikata K, Nangaku M, Wada T, Okuda Y, Sawanobori T. Ito S, et al. Clin J Am Soc Nephrol. 2020 Dec 7;15(12):1715-1727. doi: 10.2215/CJN.06870520. Epub 2020 Nov 25. Clin J Am Soc Nephrol. 2020. PMID: 33239409 Free PMC article. Clinical Trial.

2

Efficacy and safety of esaxerenone (CS-3150) for the treatment of essential hypertension: a phase 2 randomized, placebo-controlled, double-blind study.

Ito S, Itoh H, Rakugi H, Okuda Y, Yamakawa S. Ito S, et al. J Hum Hypertens. 2019 Jul;33(7):542-551. doi: 10.1038/s41371-019-0207-x. Epub 2019 May 21. J Hum Hypertens. 2019. PMID: 31113987 Free PMC article. Clinical Trial.

3

Efficacy and safety of dosage-escalation of low-dosage esaxerenone added to a RAS inhibitor in hypertensive patients with type 2 diabetes and albuminuria: a single-arm, open-label study.

Itoh H, Ito S, Rakugi H, Okuda Y, Nishioka S. Itoh H, et al. Among authors: ito s. Hypertens Res. 2019 Oct;42(10):1572-1581. doi: 10.1038/s41440-019-0270-2. Epub 2019 Jun 25. Hypertens Res. 2019. PMID: 31239535 Free PMC article.

4

Efficacy and Safety of Esaxerenone (CS-3150) for the Treatment of Type 2 Diabetes with Microalbuminuria: A Randomized, Double-Blind, Placebo-Controlled, Phase II Trial.

Ito S, Shikata K, Nangaku M, Okuda Y, Sawanobori T. Ito S, et al. Clin J Am Soc Nephrol. 2019 Aug 7;14(8):1161-1172. doi: 10.2215/CJN.14751218. Epub 2019 Jun 27. Clin J Am Soc Nephrol. 2019. PMID: 31248950 Free PMC article. Clinical Trial.

5

Long-term phase 3 study of esaxerenone as mono or combination therapy with other antihypertensive drugs in patients with essential hypertension.

Rakugi H, Ito S, Itoh H, Okuda Y, Yamakawa S. Rakugi H, et al. Among authors: ito s. Hypertens Res. 2019 Dec;42(12):1932-1941. doi: 10.1038/s41440-019-0314-7. Epub 2019 Sep 25. Hypertens Res. 2019. PMID: 31554937 Free PMC article. Clinical Trial.

6

Double-Blind Randomized Phase 3 Study Comparing Esaxerenone (CS-3150) and Eplerenone in Patients With Essential Hypertension (ESAX-HTN Study).

Ito S, Itoh H, Rakugi H, Okuda Y, Yoshimura M, Yamakawa S. Ito S, et al. Hypertension. 2020 Jan;75(1):51-58. doi: 10.1161/HYPERTENSIONAHA.119.13569. Epub 2019 Dec 2. Hypertension. 2020. PMID: 31786983 Free article. Clinical Trial.

7

Effect of the Nonsteroidal Mineralocorticoid Receptor Blocker, Esaxerenone, on Nocturnal Hypertension: A Post Hoc Analysis of the ESAX-HTN Study.

Kario K, Ito S, Itoh H, Rakugi H, Okuda Y, Yoshimura M, Yamakawa S. Kario K, et al. Among authors: ito s. Am J Hypertens. 2021 May 22;34(5):540-551. doi: 10.1093/ajh/hpaa155. Am J Hypertens. 2021. PMID: 33165570 Free PMC article. Clinical Trial.

8

Antihypertensive effects and safety of esaxerenone in patients with moderate kidney dysfunction.

Ito S, Itoh H, Rakugi H, Okuda Y, Iijima S. Ito S, et al. Hypertens Res. 2021 May;44(5):489-497. doi: 10.1038/s41440-020-00585-y. Epub 2020 Dec 16. Hypertens Res. 2021. PMID: 33323991 Free PMC article.

9

Efficacy and safety of esaxerenone (CS-3150) in Japanese patients with type 2 diabetes and macroalbuminuria: a multicenter, single-arm, open-label phase III study.

Ito S, Kashihara N, Shikata K, Nangaku M, Wada T, Okuda Y, Sawanobori T. Ito S, et al. Clin Exp Nephrol. 2021 Oct;25(10):1070-1078. doi: 10.1007/s10157-021-02075-y. Epub 2021 Jun 10. Clin Exp Nephrol. 2021. PMID: 34110524 Free PMC article. Clinical Trial.

10

Reduction in the magnitude of serum potassium elevation in combination therapy with esaxerenone (CS-3150) and sodium-glucose cotransporter 2 inhibitor in patients with diabetic kidney disease: Subanalysis of two phase III studies.

Shikata K, Ito S, Kashihara N, Nangaku M, Wada T, Okuda Y, Sawanobori T, Sugimoto K. Shikata K, et al. Among authors: ito s. J Diabetes Investig. 2022 Jul;13(7):1190-1202. doi: 10.1111/jdi.13778. Epub 2022 Apr 21. J Diabetes Investig. 2022. PMID: 35199478 Free PMC article. Clinical Trial.

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