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A novel G protein-biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein-coupled receptor kinase.
Br J Pharmacol. 2023 Apr;180(7):943-957. doi: 10.1111/bph.15334. Epub 2020 Dec 27.
Br J Pharmacol. 2023.
PMID: 33245558
Free article.
A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening.
Kaufmann J, Blum NK, Nagel F, Schuler A, Drube J, Degenhart C, Engel J, Eickhoff JE, Dasgupta P, Fritzwanker S, Guastadisegni M, Schulte C, Miess-Tanneberg E, Maric HM, Spetea M, Kliewer A, Baumann M, Klebl B, Reinscheid RK, Hoffmann C, Schulz S.
Kaufmann J, et al. Among authors: blum nk.
Commun Biol. 2022 Nov 9;5(1):1206. doi: 10.1038/s42003-022-04135-9.
Commun Biol. 2022.
PMID: 36352263
Free PMC article.
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Modulation of G-protein activation, calcium currents and opioid receptor phosphorylation by the pH-dependent antinociceptive agonist NFEPP.
Celik MÖ, Seitz V, Yergöz F, Dembla S, Blum NK, Schulz S, Stein C.
Celik MÖ, et al. Among authors: blum nk.
Front Mol Neurosci. 2023 May 12;16:1171855. doi: 10.3389/fnmol.2023.1171855. eCollection 2023.
Front Mol Neurosci. 2023.
PMID: 37251645
Free PMC article.
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Rapid elucidation of agonist-driven regulation of the neurokinin 1 receptor using a GPCR phosphorylation immunoassay.
Blum NK, Schaffner A, Drube J, Nagel F, Reinscheid RK, Hoffmann C, Schulz S.
Blum NK, et al.
Eur J Pharmacol. 2024 Jun 15;973:176587. doi: 10.1016/j.ejphar.2024.176587. Epub 2024 Apr 19.
Eur J Pharmacol. 2024.
PMID: 38642667
Free article.
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Reply to: How carvedilol does not activate β2-adrenoceptors.
Kostenis E, Gomeza J, Miess-Tanneberg E, Blum NK, Benkel T, Chevigné A, Hoffmann C, Kolb P, Nikolaev V, Waldhoer M, Szpakowska M, Inoue A, Schulz S.
Kostenis E, et al. Among authors: blum nk.
Nat Commun. 2023 Nov 30;14(1):7867. doi: 10.1038/s41467-023-42849-4.
Nat Commun. 2023.
PMID: 38036502
Free PMC article.
No abstract available.
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