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A novel G protein-biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein-coupled receptor kinase.
Br J Pharmacol. 2023 Apr;180(7):943-957. doi: 10.1111/bph.15334. Epub 2020 Dec 27.
Br J Pharmacol. 2023.
PMID: 33245558
Free article.
A Biased View of μ-Opioid Receptors?
Conibear AE, Kelly E.
Conibear AE, et al.
Mol Pharmacol. 2019 Nov;96(5):542-549. doi: 10.1124/mol.119.115956. Epub 2019 Jun 7.
Mol Pharmacol. 2019.
PMID: 31175184
Free PMC article.
Review.
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A Novel G Protein-Biased Agonist at the δ Opioid Receptor with Analgesic Efficacy in Models of Chronic Pain.
Conibear AE, Asghar J, Hill R, Henderson G, Borbely E, Tekus V, Helyes Z, Palandri J, Bailey C, Starke I, von Mentzer B, Kendall D, Kelly E.
Conibear AE, et al.
J Pharmacol Exp Ther. 2020 Feb;372(2):224-236. doi: 10.1124/jpet.119.258640. Epub 2019 Oct 8.
J Pharmacol Exp Ther. 2020.
PMID: 31594792
Free PMC article.
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The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception.
Hill R, Disney A, Conibear A, Sutcliffe K, Dewey W, Husbands S, Bailey C, Kelly E, Henderson G.
Hill R, et al.
Br J Pharmacol. 2018 Jul;175(13):2653-2661. doi: 10.1111/bph.14224. Epub 2018 May 14.
Br J Pharmacol. 2018.
PMID: 29582414
Free PMC article.
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Biased Agonism: Lessons from Studies of Opioid Receptor Agonists.
Kelly E, Conibear A, Henderson G.
Kelly E, et al.
Annu Rev Pharmacol Toxicol. 2023 Jan 20;63:491-515. doi: 10.1146/annurev-pharmtox-052120-091058. Epub 2022 Sep 28.
Annu Rev Pharmacol Toxicol. 2023.
PMID: 36170657
Free article.
Review.
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Role of Acetaldehyde in Ethanol Reversal of Tolerance to Morphine-Induced Respiratory Depression in Mice.
Hill R, Conibear A, Dewey W, Kelly E, Henderson G.
Hill R, et al.
Adv Drug Alcohol Res. 2022 Jan 31;1:10143. doi: 10.3389/adar.2021.10143.
Adv Drug Alcohol Res. 2022.
PMID: 35909497
Free PMC article.
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Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor.
Aungraheeta R, Conibear A, Butler M, Kelly E, Nylander S, Mumford A, Mundell SJ.
Aungraheeta R, et al.
Blood. 2016 Dec 8;128(23):2717-2728. doi: 10.1182/blood-2016-03-707844. Epub 2016 Sep 30.
Blood. 2016.
PMID: 27694321
Free PMC article.
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