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Spatial coupling of mTOR and autophagy augments secretory phenotypes.
Narita M, Young AR, Arakawa S, Samarajiwa SA, Nakashima T, Yoshida S, Hong S, Berry LS, Reichelt S, Ferreira M, Tavaré S, Inoki K, Shimizu S, Narita M. Narita M, et al. Among authors: samarajiwa sa. Science. 2011 May 20;332(6032):966-70. doi: 10.1126/science.1205407. Epub 2011 Apr 21. Science. 2011. PMID: 21512002 Free PMC article.
Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation.
Chandra T, Kirschner K, Thuret JY, Pope BD, Ryba T, Newman S, Ahmed K, Samarajiwa SA, Salama R, Carroll T, Stark R, Janky R, Narita M, Xue L, Chicas A, Nũnez S, Janknecht R, Hayashi-Takanaka Y, Wilson MD, Marshall A, Odom DT, Babu MM, Bazett-Jones DP, Tavaré S, Edwards PA, Lowe SW, Kimura H, Gilbert DM, Narita M. Chandra T, et al. Among authors: samarajiwa sa. Mol Cell. 2012 Jul 27;47(2):203-14. doi: 10.1016/j.molcel.2012.06.010. Epub 2012 Jul 12. Mol Cell. 2012. PMID: 22795131 Free PMC article.
Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53.
Kirschner K, Samarajiwa SA, Cairns JM, Menon S, Pérez-Mancera PA, Tomimatsu K, Bermejo-Rodriguez C, Ito Y, Chandra T, Narita M, Lyons SK, Lynch AG, Kimura H, Ohbayashi T, Tavaré S, Narita M. Kirschner K, et al. Among authors: samarajiwa sa. PLoS Genet. 2015 Mar 19;11(3):e1005053. doi: 10.1371/journal.pgen.1005053. eCollection 2015 Mar. PLoS Genet. 2015. PMID: 25790137 Free PMC article.
NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence.
Parry AJ, Hoare M, Bihary D, Hänsel-Hertsch R, Smith S, Tomimatsu K, Mannion E, Smith A, D'Santos P, Russell IA, Balasubramanian S, Kimura H, Samarajiwa SA, Narita M. Parry AJ, et al. Among authors: samarajiwa sa. Nat Commun. 2018 May 9;9(1):1840. doi: 10.1038/s41467-018-04283-9. Nat Commun. 2018. PMID: 29743479 Free PMC article.
NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis.
Rodrigues P, Patel SA, Harewood L, Olan I, Vojtasova E, Syafruddin SE, Zaini MN, Richardson EK, Burge J, Warren AY, Stewart GD, Saeb-Parsy K, Samarajiwa SA, Vanharanta S. Rodrigues P, et al. Among authors: samarajiwa sa. Cancer Discov. 2018 Jul;8(7):850-865. doi: 10.1158/2159-8290.CD-17-1211. Epub 2018 Jun 6. Cancer Discov. 2018. PMID: 29875134 Free PMC article.
Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington's disease.
Alcalá-Vida R, Garcia-Forn M, Castany-Pladevall C, Creus-Muncunill J, Ito Y, Blanco E, Golbano A, Crespí-Vázquez K, Parry A, Slater G, Samarajiwa S, Peiró S, Di Croce L, Narita M, Pérez-Navarro E. Alcalá-Vida R, et al. EMBO Mol Med. 2021 Feb 5;13(2):e12105. doi: 10.15252/emmm.202012105. Epub 2020 Dec 28. EMBO Mol Med. 2021. PMID: 33369245 Free PMC article.
The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer.
Patel SA, Hirosue S, Rodrigues P, Vojtasova E, Richardson EK, Ge J, Syafruddin SE, Speed A, Papachristou EK, Baker D, Clarke D, Purvis S, Wesolowski L, Dyas A, Castillon L, Caraffini V, Bihary D, Yong C, Harrison DJ, Stewart GD, Machiela MJ, Purdue MP, Chanock SJ, Warren AY, Samarajiwa SA, Carroll JS, Vanharanta S. Patel SA, et al. Among authors: samarajiwa sa. Nature. 2022 Jun;606(7916):999-1006. doi: 10.1038/s41586-022-04809-8. Epub 2022 Jun 8. Nature. 2022. PMID: 35676472 Free PMC article.
29 results