Opferman JT - Search Results

1

The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics.

Smith KH, Budhraja A, Lynch J, Roberts K, Panetta JC, Connelly JP, Turnis ME, Pruett-Miller SM, Schuetz JD, Mullighan CG, Opferman JT. Smith KH, et al. Among authors: opferman jt. Mol Cancer Res. 2021 Apr;19(4):636-650. doi: 10.1158/1541-7786.MCR-20-0586. Epub 2020 Dec 7. Mol Cancer Res. 2021. PMID: 33288732 Free PMC article.

2

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.

Perciavalle RM, Stewart DP, Koss B, Lynch J, Milasta S, Bathina M, Temirov J, Cleland MM, Pelletier S, Schuetz JD, Youle RJ, Green DR, Opferman JT. Perciavalle RM, et al. Among authors: opferman jt. Nat Cell Biol. 2012 Apr 29;14(6):575-83. doi: 10.1038/ncb2488. Nat Cell Biol. 2012. PMID: 22544066 Free PMC article.

3

Delving deeper: MCL-1's contributions to normal and cancer biology.

Perciavalle RM, Opferman JT. Perciavalle RM, et al. Among authors: opferman jt. Trends Cell Biol. 2013 Jan;23(1):22-9. doi: 10.1016/j.tcb.2012.08.011. Epub 2012 Sep 28. Trends Cell Biol. 2013. PMID: 23026029 Free PMC article. Review.

4

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction.

Wang X, Bathina M, Lynch J, Koss B, Calabrese C, Frase S, Schuetz JD, Rehg JE, Opferman JT. Wang X, et al. Among authors: opferman jt. Genes Dev. 2013 Jun 15;27(12):1351-64. doi: 10.1101/gad.215855.113. Genes Dev. 2013. PMID: 23788622 Free PMC article.

5

Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia.

Koss B, Morrison J, Perciavalle RM, Singh H, Rehg JE, Williams RT, Opferman JT. Koss B, et al. Among authors: opferman jt. Blood. 2013 Aug 29;122(9):1587-98. doi: 10.1182/blood-2012-06-440230. Epub 2013 Jul 23. Blood. 2013. PMID: 23881917 Free PMC article.

6

Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice.

Li-Harms X, Milasta S, Lynch J, Wright C, Joshi A, Iyengar R, Neale G, Wang X, Wang YD, Prolla TA, Thompson JE, Opferman JT, Green DR, Schuetz J, Kundu M. Li-Harms X, et al. Among authors: opferman jt. Blood. 2015 Jan 1;125(1):162-74. doi: 10.1182/blood-2014-07-586396. Epub 2014 Nov 19. Blood. 2015. PMID: 25411424 Free PMC article.

7

Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members.

Opferman JT. Opferman JT. FEBS J. 2016 Jul;283(14):2661-75. doi: 10.1111/febs.13472. Epub 2015 Sep 15. FEBS J. 2016. PMID: 26293580 Free PMC article. Review.

8

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death.

Morgan JA, Lynch J, Panetta JC, Wang Y, Frase S, Bao J, Zheng J, Opferman JT, Janke L, Green DM, Chemaitilly W, Schuetz JD. Morgan JA, et al. Among authors: opferman jt. Sci Rep. 2015 Nov 18;5:16488. doi: 10.1038/srep16488. Sci Rep. 2015. PMID: 26576726 Free PMC article.

9

Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines.

Koss B, Ryan J, Budhraja A, Szarama K, Yang X, Bathina M, Cardone MH, Nikolovska-Coleska Z, Letai A, Opferman JT. Koss B, et al. Among authors: opferman jt. Oncotarget. 2016 Mar 8;7(10):11500-11. doi: 10.18632/oncotarget.7204. Oncotarget. 2016. PMID: 26862853 Free PMC article.

10

Prolyl Hydroxylase 3 Attenuates MCL-1-Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells.

Radhakrishnan P, Ruh N, Harnoss JM, Kiss J, Mollenhauer M, Scherr AL, Platzer LK, Schmidt T, Podar K, Opferman JT, Weitz J, Schulze-Bergkamen H, Koehler BC, Ulrich A, Schneider M. Radhakrishnan P, et al. Among authors: opferman jt. Cancer Res. 2016 Apr 15;76(8):2219-30. doi: 10.1158/0008-5472.CAN-15-1474. Epub 2016 Feb 26. Cancer Res. 2016. PMID: 26921340

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