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A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation.
Tadele DS, Robertson J, Crispin R, Herrera MC, Chlubnová M, Piechaczyk L, Ayuda-Durán P, Singh SK, Gedde-Dahl T, Fløisand Y, Skavland J, Wesche J, Gjertsen BT, Enserink JM. Tadele DS, et al. Among authors: wesche j. J Biol Chem. 2021 Jan-Jun;296:100179. doi: 10.1074/jbc.RA120.015285. Epub 2020 Dec 17. J Biol Chem. 2021. PMID: 33303632 Free PMC article.
GAK and PRKCD are positive regulators of PRKN-independent mitophagy.
Munson MJ, Mathai BJ, Ng MYW, Trachsel-Moncho L, de la Ballina LR, Schultz SW, Aman Y, Lystad AH, Singh S, Singh S, Wesche J, Fang EF, Simonsen A. Munson MJ, et al. Among authors: wesche j. Nat Commun. 2021 Oct 20;12(1):6101. doi: 10.1038/s41467-021-26331-7. Nat Commun. 2021. PMID: 34671015 Free PMC article.
Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma.
Fiorito E, Szybowska P, Haugsten EM, Kostas M, Øy GF, Wiedlocha A, Singh S, Nakken S, Mælandsmo GM, Fletcher JA, Meza-Zepeda LA, Wesche J. Fiorito E, et al. Among authors: wesche j. Br J Cancer. 2022 Nov;127(11):1939-1953. doi: 10.1038/s41416-022-01973-6. Epub 2022 Sep 12. Br J Cancer. 2022. PMID: 36097178 Free PMC article.
Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors.
Kostas M, Haugsten EM, Zhen Y, Sørensen V, Szybowska P, Fiorito E, Lorenz S, Jones N, de Souza GA, Wiedlocha A, Wesche J. Kostas M, et al. Among authors: wesche j. Mol Cell Proteomics. 2018 May;17(5):850-870. doi: 10.1074/mcp.RA117.000538. Epub 2018 Jan 25. Mol Cell Proteomics. 2018. PMID: 29371290 Free PMC article.
133 results