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Kinomic profiling of tumour xenografts derived from patients with non-small cell lung cancer confirms their fidelity and reveals potentially actionable pathways.
Tabbò F, Guerrera F, van den Berg A, Gaudiano M, Maletta F, Bessone L, Nottegar A, Costardi L, de Wijn R, Ruijtenbeek R, Delsedime L, Sapino A, Ruffini E, Hilhorst R, Inghirami G. Tabbò F, et al. Among authors: hilhorst r. Eur J Cancer. 2021 Feb;144:17-30. doi: 10.1016/j.ejca.2020.10.036. Epub 2020 Dec 11. Eur J Cancer. 2021. PMID: 33316635
Protein kinase activity profiling of postmortem human brain tissue.
Hoozemans JJ, Hilhorst R, Ruijtenbeek R, Rozemuller AJ, van der Vies SM. Hoozemans JJ, et al. Among authors: hilhorst r. Neurodegener Dis. 2012;10(1-4):46-8. doi: 10.1159/000335914. Epub 2012 Feb 16. Neurodegener Dis. 2012. PMID: 22343098
AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and dose dependent reduction of tyrosine kinase activity in acute myeloid leukemia.
Eriksson A, Kalushkova A, Jarvius M, Hilhorst R, Rickardson L, Kultima HG, de Wijn R, Hovestad L, Fryknäs M, Öberg F, Larsson R, Parrow V, Höglund M. Eriksson A, et al. Among authors: hilhorst r. Biochem Pharmacol. 2014 Jan 15;87(2):284-91. doi: 10.1016/j.bcp.2013.10.022. Epub 2013 Nov 4. Biochem Pharmacol. 2014. PMID: 24200998 Free article. Clinical Trial.
Inactive immune pathways in triple negative breast cancers that showed resistance to neoadjuvant chemotherapy as inferred from kinase activity profiles.
Sawada T, Hilhorst R, Rangarajan S, Yoshida M, Tanabe Y, Tamura K, Kinoshita T, Shimoyama T, van Beuningen R, Ruijtenbeek R, Tsuda H, Koizumi F. Sawada T, et al. Among authors: hilhorst r. Oncotarget. 2018 Sep 28;9(76):34229-34239. doi: 10.18632/oncotarget.26026. eCollection 2018 Sep 28. Oncotarget. 2018. PMID: 30344939 Free PMC article.
Kinome Profiling to Predict Sensitivity to MAPK Inhibition in Melanoma and to Provide New Insights into Intrinsic and Acquired Mechanism of Resistance.
Krayem M, Aftimos P, Najem A, van den Hooven T, van den Berg A, Hovestad-Bijl L, de Wijn R, Hilhorst R, Ruijtenbeek R, Sabbah M, Kerger J, Awada A, Journe F, Ghanem GE. Krayem M, et al. Among authors: hilhorst r. Cancers (Basel). 2020 Feb 22;12(2):512. doi: 10.3390/cancers12020512. Cancers (Basel). 2020. PMID: 32098410 Free PMC article.
54 results