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PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury.
J Clin Invest. 2021 Feb 15;131(4):e140196. doi: 10.1172/JCI140196.
J Clin Invest. 2021.
PMID: 33320839
Free PMC article.
Activation and transcriptional profile of monocytes and CD8+ T cells are altered in checkpoint inhibitor-related hepatitis.
Gudd CLC, Au L, Triantafyllou E, Shum B, Liu T, Nathwani R, Kumar N, Mukherjee S, Dhar A, Woollard KJ, Yone Y, Pinato DJ, Thursz MR, Goldin RD, Gore ME, Larkin J, Khamri W, Antoniades CG, Turajlic S, Possamai LA.
Gudd CLC, et al.
J Hepatol. 2021 Jul;75(1):177-189. doi: 10.1016/j.jhep.2021.02.008. Epub 2021 Feb 22.
J Hepatol. 2021.
PMID: 33631227
Free article.
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Suppressor CD4+ T cells expressing HLA-G are expanded in the peripheral blood from patients with acute decompensation of cirrhosis.
Khamri W, Gudd C, Liu T, Nathwani R, Krasniqi M, Azam S, Barbera T, Trovato FM, Possamai L, Triantafyllou E, Seoane RC, Lebosse F, Singanayagam A, Kumar N, Bernsmeier C, Mukherjee S, McPhail M, Weston CJ, Antoniades CG, Thursz MR.
Khamri W, et al.
Gut. 2022 Jun;71(6):1192-1202. doi: 10.1136/gutjnl-2021-324071. Epub 2021 Aug 3.
Gut. 2022.
PMID: 34344786
Free PMC article.
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CD8+T cells from patients with cirrhosis display a phenotype that may contribute to cirrhosis-associated immune dysfunction.
Lebossé F, Gudd C, Tunc E, Singanayagam A, Nathwani R, Triantafyllou E, Pop O, Kumar N, Mukherjee S, Hou TZ, Quaglia A, Zoulim F, Wendon J, Dhar A, Thursz M, Antoniades CG, Khamri W.
Lebossé F, et al.
EBioMedicine. 2019 Nov;49:258-268. doi: 10.1016/j.ebiom.2019.10.011. Epub 2019 Oct 31.
EBioMedicine. 2019.
PMID: 31678004
Free PMC article.
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The Role of Myeloid Cells in Hepatotoxicity Related to Cancer Immunotherapy.
Gudd CLC, Possamai LA.
Gudd CLC, et al.
Cancers (Basel). 2022 Apr 10;14(8):1913. doi: 10.3390/cancers14081913.
Cancers (Basel). 2022.
PMID: 35454819
Free PMC article.
Review.
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Immunotoxicity from checkpoint inhibitor therapy: clinical features and underlying mechanisms.
Fessas P, Possamai LA, Clark J, Daniels E, Gudd C, Mullish BH, Alexander JL, Pinato DJ.
Fessas P, et al.
Immunology. 2020 Feb;159(2):167-177. doi: 10.1111/imm.13141. Epub 2019 Nov 19.
Immunology. 2020.
PMID: 31646612
Free PMC article.
Review.
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Therapeutic inhibition of monocyte recruitment prevents checkpoint inhibitor-induced hepatitis.
Gudd CLC, Mitchell E, Atkinson SR, Mawhin MA, Turajlic S, Larkin J, Thursz MR, Goldin RD, Powell N, Antoniades CG, Woollard KJ, Possamai LA, Triantafyllou E.
Gudd CLC, et al.
J Immunother Cancer. 2024 Apr 4;12(4):e008078. doi: 10.1136/jitc-2023-008078.
J Immunother Cancer. 2024.
PMID: 38580334
Free PMC article.
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Immune Checkpoint Inhibitor-Induced Liver Injury.
Gudd CLC, Sheth R, Thursz MR, Triantafyllou E, Possamai LA.
Gudd CLC, et al.
Semin Liver Dis. 2023 Nov;43(4):402-417. doi: 10.1055/s-0043-1776761. Epub 2023 Dec 15.
Semin Liver Dis. 2023.
PMID: 38101418
Review.
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