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Attenuated CSF-1R signalling drives cerebrovascular pathology.
Delaney C, Farrell M, Doherty CP, Brennan K, O'Keeffe E, Greene C, Byrne K, Kelly E, Birmingham N, Hickey P, Cronin S, Savvides SN, Doyle SL, Campbell M. Delaney C, et al. Among authors: brennan k. EMBO Mol Med. 2021 Feb 5;13(2):e12889. doi: 10.15252/emmm.202012889. Epub 2020 Dec 22. EMBO Mol Med. 2021. PMID: 33350588 Free PMC article.
IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration.
Doyle SL, Ozaki E, Brennan K, Humphries MM, Mulfaul K, Keaney J, Kenna PF, Maminishkis A, Kiang AS, Saunders SP, Hams E, Lavelle EC, Gardiner C, Fallon PG, Adamson P, Humphries P, Campbell M. Doyle SL, et al. Among authors: brennan k. Sci Transl Med. 2014 Apr 2;6(230):230ra44. doi: 10.1126/scitranslmed.3007616. Sci Transl Med. 2014. PMID: 24695684
IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates.
Doyle SL, López FJ, Celkova L, Brennan K, Mulfaul K, Ozaki E, Kenna PF, Kurali E, Hudson N, Doggett T, Ferguson TA, Humphries P, Adamson P, Campbell M. Doyle SL, et al. Among authors: brennan k. Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5424-30. doi: 10.1167/iovs.15-17264. Invest Ophthalmol Vis Sci. 2015. PMID: 26284546
Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation.
Brennan K, O'Leary BD, Mc Laughlin D, Breen EP, Connolly E, Ali N, O'Driscoll DN, Ozaki E, Mahony R, Mulfaul K, Ryan AM, Ni Chianain A, McHugh A, Molloy EJ, Hogan AE, Paran S, McAuliffe FM, Doyle SL. Brennan K, et al. J Immunol. 2018 Aug 15;201(4):1131-1143. doi: 10.4049/jimmunol.1700956. Epub 2018 Jul 6. J Immunol. 2018. PMID: 29980613
Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies.
Ui Mhaonaigh A, Coughlan AM, Dwivedi A, Hartnett J, Cabral J, Moran B, Brennan K, Doyle SL, Hughes K, Lucey R, Floudas A, Fearon U, McGrath S, Cormican S, De Bhailis A, Molloy EJ, Brady G, Little MA. Ui Mhaonaigh A, et al. Among authors: brennan k. Front Immunol. 2019 Nov 7;10:2603. doi: 10.3389/fimmu.2019.02603. eCollection 2019. Front Immunol. 2019. PMID: 31781107 Free PMC article.
Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration.
Mulfaul K, Ozaki E, Fernando N, Brennan K, Chirco KR, Connolly E, Greene C, Maminishkis A, Salomon RG, Linetsky M, Natoli R, Mullins RF, Campbell M, Doyle SL. Mulfaul K, et al. Among authors: brennan k. Cell Rep. 2020 Feb 18;30(7):2209-2224.e5. doi: 10.1016/j.celrep.2020.01.064. Cell Rep. 2020. PMID: 32075760 Free PMC article.
Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis.
Useckaite Z, Ward MP, Trappe A, Reilly R, Lennon J, Davage H, Matallanas D, Cassidy H, Dillon ET, Brennan K, Doyle SL, Carter S, Donnelly S, Linnane B, McKone EF, McNally P, Coppinger JA. Useckaite Z, et al. Among authors: brennan k. Thorax. 2020 Jun;75(6):449-458. doi: 10.1136/thoraxjnl-2019-214027. Epub 2020 Apr 7. Thorax. 2020. PMID: 32265339 Free PMC article.
599 results