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Discovery of dual function acridones as a new antimalarial chemotype.
Kelly JX, Smilkstein MJ, Brun R, Wittlin S, Cooper RA, Lane KD, Janowsky A, Johnson RA, Dodean RA, Winter R, Hinrichs DJ, Riscoe MK. Kelly JX, et al. Among authors: smilkstein mj. Nature. 2009 May 14;459(7244):270-3. doi: 10.1038/nature07937. Epub 2009 Apr 8. Nature. 2009. PMID: 19357645 Free PMC article.
Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria.
Frueh L, Li Y, Mather MW, Li Q, Pou S, Nilsen A, Winter RW, Forquer IP, Pershing AM, Xie LH, Smilkstein MJ, Caridha D, Koop DR, Campbell RF, Sciotti RJ, Kreishman-Deitrick M, Kelly JX, Vesely B, Vaidya AB, Riscoe MK. Frueh L, et al. Among authors: smilkstein mj. ACS Infect Dis. 2017 Oct 13;3(10):728-735. doi: 10.1021/acsinfecdis.7b00062. Epub 2017 Sep 27. ACS Infect Dis. 2017. PMID: 28927276 Free PMC article.
Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis.
McConnell EV, Bruzual I, Pou S, Winter R, Dodean RA, Smilkstein MJ, Krollenbrock A, Nilsen A, Zakharov LN, Riscoe MK, Doggett JS. McConnell EV, et al. Among authors: smilkstein mj. ACS Infect Dis. 2018 Nov 9;4(11):1574-1584. doi: 10.1021/acsinfecdis.8b00133. Epub 2018 Aug 30. ACS Infect Dis. 2018. PMID: 30117728 Free PMC article.
Evaluation and lead optimization of anti-malarial acridones.
Winter RW, Kelly JX, Smilkstein MJ, Dodean R, Bagby GC, Rathbun RK, Levin JI, Hinrichs D, Riscoe MK. Winter RW, et al. Among authors: smilkstein mj. Exp Parasitol. 2006 Sep;114(1):47-56. doi: 10.1016/j.exppara.2006.03.014. Epub 2006 Jul 7. Exp Parasitol. 2006. PMID: 16828746
49 results