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The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion.
Li Z, Farias FHG, Dube U, Del-Aguila JL, Mihindukulasuriya KA, Fernandez MV, Ibanez L, Budde JP, Wang F, Lake AM, Deming Y, Perez J, Yang C, Bahena JA, Qin W, Bradley JL, Davenport R, Bergmann K, Morris JC, Perrin RJ, Benitez BA, Dougherty JD, Harari O, Cruchaga C. Li Z, et al. Among authors: lake am. Acta Neuropathol. 2020 Jan;139(1):45-61. doi: 10.1007/s00401-019-02066-0. Epub 2019 Aug 27. Acta Neuropathol. 2020. PMID: 31456032 Free PMC article.
Astrocytes locally translate transcripts in their peripheral processes.
Sakers K, Lake AM, Khazanchi R, Ouwenga R, Vasek MJ, Dani A, Dougherty JD. Sakers K, et al. Among authors: lake am. Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3830-E3838. doi: 10.1073/pnas.1617782114. Epub 2017 Apr 24. Proc Natl Acad Sci U S A. 2017. PMID: 28439016 Free PMC article. Review.
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