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Cell type-specific transcriptomics identifies neddylation as a novel therapeutic target in multiple sclerosis.
Kim K, Pröbstel AK, Baumann R, Dyckow J, Landefeld J, Kogl E, Madireddy L, Loudermilk R, Eggers EL, Singh S, Caillier SJ, Hauser SL, Cree BAC; UCSF MS-EPIC Team; Schirmer L, Wilson MR, Baranzini SE. Kim K, et al. Among authors: eggers el. Brain. 2021 Mar 3;144(2):450-461. doi: 10.1093/brain/awaa421. Brain. 2021. PMID: 33374005 Free PMC article.
Clonal relationships of CSF B cells in treatment-naive multiple sclerosis patients.
Eggers EL, Michel BA, Wu H, Wang SZ, Bevan CJ, Abounasr A, Pierson NS, Bischof A, Kazer M, Leitner E, Greenfield AL, Demuth S, Wilson MR, Henry RG, Cree BA, Hauser SL, von Büdingen HC. Eggers EL, et al. JCI Insight. 2017 Nov 16;2(22):e92724. doi: 10.1172/jci.insight.92724. eCollection 2017 Nov 16. JCI Insight. 2017. PMID: 29202449 Free PMC article.
Longitudinally persistent cerebrospinal fluid B cells can resist treatment in multiple sclerosis.
Greenfield AL, Dandekar R, Ramesh A, Eggers EL, Wu H, Laurent S, Harkin W, Pierson NS, Weber MS, Henry RG, Bischof A, Cree BA, Hauser SL, Wilson MR, von Büdingen HC. Greenfield AL, et al. Among authors: eggers el. JCI Insight. 2019 Mar 21;4(6):e126599. doi: 10.1172/jci.insight.126599. eCollection 2019 Mar 21. JCI Insight. 2019. PMID: 30747723 Free PMC article.
Effect of Ocrelizumab on B- and T-Cell Receptor Repertoire Diversity in Patients With Relapsing Multiple Sclerosis From the Randomized Phase III OPERA Trial.
Laurent SA, Strauli NB, Eggers EL, Wu H, Michel B, Demuth S, Palanichamy A, Wilson MR, Sirota M, Hernandez RD, Cree BAC, Herman AE, von Büdingen HC. Laurent SA, et al. Among authors: eggers el. Neurol Neuroimmunol Neuroinflamm. 2023 Apr 24;10(4):e200118. doi: 10.1212/NXI.0000000000200118. Print 2023 Jul. Neurol Neuroimmunol Neuroinflamm. 2023. PMID: 37094998 Free PMC article. Clinical Trial.
A Predictive Autoantibody Signature in Multiple Sclerosis.
Zamecnik CR, Sowa GM, Abdelhak A, Dandekar R, Bair RD, Wade KJ, Bartley CM, Tubati A, Gomez R, Fouassier C, Gerungan C, Alexander J, Wapniarski AE, Loudermilk RP, Eggers EL, Zorn KC, Ananth K, Jabassini N, Mann SA, Ragan NR, Santaniello A, Henry RG, Baranzini SE, Zamvil SS, Bove RM, Guo CY, Gelfand JM, Cuneo R, von Büdingen HC, Oksenberg JR, Cree BA, Hollenbach JA, Green AJ, Hauser SL, Wallin MT, DeRisi JL, Wilson MR. Zamecnik CR, et al. Among authors: eggers el. medRxiv [Preprint]. 2023 May 15:2023.05.01.23288943. doi: 10.1101/2023.05.01.23288943. medRxiv. 2023. PMID: 37205595 Free PMC article. Preprint.
An autoantibody signature predictive for multiple sclerosis.
Zamecnik CR, Sowa GM, Abdelhak A, Dandekar R, Bair RD, Wade KJ, Bartley CM, Kizer K, Augusto DG, Tubati A, Gomez R, Fouassier C, Gerungan C, Caspar CM, Alexander J, Wapniarski AE, Loudermilk RP, Eggers EL, Zorn KC, Ananth K, Jabassini N, Mann SA, Ragan NR, Santaniello A, Henry RG, Baranzini SE, Zamvil SS, Sabatino JJ Jr, Bove RM, Guo CY, Gelfand JM, Cuneo R, von Büdingen HC, Oksenberg JR, Cree BAC, Hollenbach JA, Green AJ, Hauser SL, Wallin MT, DeRisi JL, Wilson MR. Zamecnik CR, et al. Among authors: eggers el. Nat Med. 2024 May;30(5):1300-1308. doi: 10.1038/s41591-024-02938-3. Epub 2024 Apr 19. Nat Med. 2024. PMID: 38641750