Guan KL - Search Results

1

Structural insights into TSC complex assembly and GAP activity on Rheb.

Yang H, Yu Z, Chen X, Li J, Li N, Cheng J, Gao N, Yuan HX, Ye D, Guan KL, Xu Y. Yang H, et al. Among authors: guan kl. Nat Commun. 2021 Jan 12;12(1):339. doi: 10.1038/s41467-020-20522-4. Nat Commun. 2021. PMID: 33436626 Free PMC article.

2

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.

Li Y, Inoki K, Guan KL. Li Y, et al. Among authors: guan kl. Mol Cell Biol. 2004 Sep;24(18):7965-75. doi: 10.1128/MCB.24.18.7965-7975.2004. Mol Cell Biol. 2004. PMID: 15340059 Free PMC article.

3

Structural basis for the unique biological function of small GTPase RHEB.

Yu Y, Li S, Xu X, Li Y, Guan K, Arnold E, Ding J. Yu Y, et al. J Biol Chem. 2005 Apr 29;280(17):17093-100. doi: 10.1074/jbc.M501253200. Epub 2005 Feb 23. J Biol Chem. 2005. PMID: 15728574 Free article.

4

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.

Yang Q, Inoki K, Kim E, Guan KL. Yang Q, et al. Among authors: guan kl. Proc Natl Acad Sci U S A. 2006 May 2;103(18):6811-6. doi: 10.1073/pnas.0602282103. Epub 2006 Apr 20. Proc Natl Acad Sci U S A. 2006. PMID: 16627617 Free PMC article.

5

Measurements of TSC2 GAP activity toward Rheb.

Li Y, Inoki K, Vikis H, Guan KL. Li Y, et al. Among authors: guan kl. Methods Enzymol. 2006;407:46-54. doi: 10.1016/S0076-6879(05)07005-9. Methods Enzymol. 2006. PMID: 16757313

6

Structural insights into the YAP and TEAD complex.

Li Z, Zhao B, Wang P, Chen F, Dong Z, Yang H, Guan KL, Xu Y. Li Z, et al. Among authors: guan kl. Genes Dev. 2010 Feb 1;24(3):235-40. doi: 10.1101/gad.1865810. Genes Dev. 2010. PMID: 20123905 Free PMC article.

7

Regulation of mTORC1 by the Rab and Arf GTPases.

Li L, Kim E, Yuan H, Inoki K, Goraksha-Hicks P, Schiesher RL, Neufeld TP, Guan KL. Li L, et al. Among authors: guan kl. J Biol Chem. 2010 Jun 25;285(26):19705-9. doi: 10.1074/jbc.C110.102483. Epub 2010 May 10. J Biol Chem. 2010. PMID: 20457610 Free PMC article.

8

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.

Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu LX, Jiang WQ, Liu J, Zhang JY, Wang B, Frye S, Zhang Y, Xu YH, Lei QY, Guan KL, Zhao SM, Xiong Y. Xu W, et al. Among authors: guan kl. Cancer Cell. 2011 Jan 18;19(1):17-30. doi: 10.1016/j.ccr.2010.12.014. Cancer Cell. 2011. PMID: 21251613 Free PMC article.

9

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.

Zheng M, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ, Zhang H, Sun P, Lin SC, Guan KL, Han J. Zheng M, et al. Among authors: guan kl. Nat Cell Biol. 2011 Mar;13(3):263-72. doi: 10.1038/ncb2168. Epub 2011 Feb 20. Nat Cell Biol. 2011. PMID: 21336308 Free PMC article.

10

Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway.

Yoshida S, Hong S, Suzuki T, Nada S, Mannan AM, Wang J, Okada M, Guan KL, Inoki K. Yoshida S, et al. Among authors: guan kl. J Biol Chem. 2011 Sep 16;286(37):32651-60. doi: 10.1074/jbc.M111.238014. Epub 2011 Jul 22. J Biol Chem. 2011. PMID: 21784859 Free PMC article.

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