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Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders.
Johmura Y, Yamanaka T, Omori S, Wang TW, Sugiura Y, Matsumoto M, Suzuki N, Kumamoto S, Yamaguchi K, Hatakeyama S, Takami T, Yamaguchi R, Shimizu E, Ikeda K, Okahashi N, Mikawa R, Suematsu M, Arita M, Sugimoto M, Nakayama KI, Furukawa Y, Imoto S, Nakanishi M. Johmura Y, et al. Among authors: suzuki n. Science. 2021 Jan 15;371(6526):265-270. doi: 10.1126/science.abb5916. Science. 2021. PMID: 33446552
Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.
Johmura Y, Maeda I, Suzuki N, Wu W, Goda A, Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T, Akiyama F, Maruyama R, Inoue JI, Furukawa Y, Ohta T, Nakanishi M. Johmura Y, et al. Among authors: suzuki n. J Clin Invest. 2018 Dec 3;128(12):5603-5619. doi: 10.1172/JCI121679. Epub 2018 Nov 12. J Clin Invest. 2018. PMID: 30418174 Free PMC article.
TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis.
Suzuki N, Johmura Y, Wang TW, Migita T, Wu W, Noguchi R, Yamaguchi K, Furukawa Y, Nakamura S, Miyoshi I, Yoshimori T, Ohta T, Nakanishi M. Suzuki N, et al. Autophagy. 2021 Nov;17(11):3776-3793. doi: 10.1080/15548627.2021.1897961. Epub 2021 Mar 11. Autophagy. 2021. PMID: 33706682 Free PMC article.
Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes.
Wang TW, Johmura Y, Suzuki N, Omori S, Migita T, Yamaguchi K, Hatakeyama S, Yamazaki S, Shimizu E, Imoto S, Furukawa Y, Yoshimura A, Nakanishi M. Wang TW, et al. Among authors: suzuki n. Nature. 2022 Nov;611(7935):358-364. doi: 10.1038/s41586-022-05388-4. Epub 2022 Nov 2. Nature. 2022. PMID: 36323784
LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits.
Li D, Johmura Y, Morimoto S, Doi M, Nakanishi K, Ozawa M, Tsunekawa Y, Inoue-Yamauchi A, Naruse H, Matsukawa T, Takeshita Y, Suzuki N, Aoki M, Nishiyama A, Zeng X, Konishi C, Suzuki N, Nishiyama A, Harris AS, Morita M, Yamaguchi K, Furukawa Y, Nakai K, Tsuji S, Yamazaki S, Yamanashi Y, Shimada S, Okada T, Okano H, Toda T, Nakanishi M. Li D, et al. Among authors: suzuki n. Nat Aging. 2023 Aug;3(8):1001-1019. doi: 10.1038/s43587-023-00464-4. Epub 2023 Jul 20. Nat Aging. 2023. PMID: 37474791
A phase 1/1b, open-label, dose-escalation study of PD-1 inhibitor, cetrelimab alone and in combination with FGFR inhibitor, erdafitinib in Japanese patients with advanced solid tumors.
Yamamoto N, Kuboki Y, Harano K, Koyama T, Kondo S, Hagiwara A, Suzuki N, Fujikawa E, Toyoizumi K, Mukai M, Doi T. Yamamoto N, et al. Among authors: suzuki n. Invest New Drugs. 2024 Jun 4. doi: 10.1007/s10637-024-01433-3. Online ahead of print. Invest New Drugs. 2024. PMID: 38833067
Two structurally different oomycete lipophilic microbe-associated molecular patterns induce distinctive plant immune responses.
Monjil MS, Kato H, Ota S, Matsuda K, Suzuki N, Tenhiro S, Tatsumi A, Pring S, Miura A, Camagna M, Suzuki T, Tanaka A, Terauchi R, Sato I, Chiba S, Kawakita K, Ojika M, Takemoto D. Monjil MS, et al. Among authors: suzuki n. Plant Physiol. 2024 Jun 3:kiae255. doi: 10.1093/plphys/kiae255. Online ahead of print. Plant Physiol. 2024. PMID: 38828881
PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity.
Sekine H, Takeda H, Takeda N, Kishino A, Anzawa H, Isagawa T, Ohta N, Murakami S, Iwaki H, Kato N, Kimura S, Liu Z, Kato K, Katsuoka F, Yamamoto M, Miura F, Ito T, Takahashi M, Izumi Y, Fujita H, Yamagata H, Bamba T, Akaike T, Suzuki N, Kinoshita K, Motohashi H. Sekine H, et al. Among authors: suzuki n. Nat Metab. 2024 May 31. doi: 10.1038/s42255-024-01053-4. Online ahead of print. Nat Metab. 2024. PMID: 38822028
6,034 results