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Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress.
Montaser H, Patel KA, Balboa D, Ibrahim H, Lithovius V, Näätänen A, Chandra V, Demir K, Acar S, Ben-Omran T, Colclough K, Locke JM, Wakeling M, Lindahl M, Hattersley AT, Saarimäki-Vire J, Otonkoski T. Montaser H, et al. Among authors: lindahl m. Diabetes. 2021 Apr;70(4):1006-1018. doi: 10.2337/db20-1174. Epub 2021 Jan 26. Diabetes. 2021. PMID: 33500254 Free PMC article.
MANF is indispensable for the proliferation and survival of pancreatic β cells.
Lindahl M, Danilova T, Palm E, Lindholm P, Võikar V, Hakonen E, Ustinov J, Andressoo JO, Harvey BK, Otonkoski T, Rossi J, Saarma M. Lindahl M, et al. Cell Rep. 2014 Apr 24;7(2):366-375. doi: 10.1016/j.celrep.2014.03.023. Epub 2014 Apr 13. Cell Rep. 2014. PMID: 24726366 Free PMC article.
Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).
Cunha DA, Cito M, Grieco FA, Cosentino C, Danilova T, Ladrière L, Lindahl M, Domanskyi A, Bugliani M, Marchetti P, Eizirik DL, Cnop M. Cunha DA, et al. Among authors: lindahl m. J Biol Chem. 2017 Sep 8;292(36):14977-14988. doi: 10.1074/jbc.M116.769877. Epub 2017 Jul 11. J Biol Chem. 2017. PMID: 28698383 Free PMC article.
MANF protects human pancreatic beta cells against stress-induced cell death.
Hakonen E, Chandra V, Fogarty CL, Yu NY, Ustinov J, Katayama S, Galli E, Danilova T, Lindholm P, Vartiainen A, Einarsdottir E, Krjutškov K, Kere J, Saarma M, Lindahl M, Otonkoski T. Hakonen E, et al. Among authors: lindahl m. Diabetologia. 2018 Oct;61(10):2202-2214. doi: 10.1007/s00125-018-4687-y. Epub 2018 Jul 21. Diabetologia. 2018. PMID: 30032427 Free PMC article.
CDNF and MANF regulate ER stress in a tissue-specific manner.
Pakarinen E, Lindholm P, Saarma M, Lindahl M. Pakarinen E, et al. Among authors: lindahl m. Cell Mol Life Sci. 2022 Feb 7;79(2):124. doi: 10.1007/s00018-022-04157-w. Cell Mol Life Sci. 2022. PMID: 35129674 Free PMC article.
212 results