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Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis.
Semple RK, Sleigh A, Murgatroyd PR, Adams CA, Bluck L, Jackson S, Vottero A, Kanabar D, Charlton-Menys V, Durrington P, Soos MA, Carpenter TA, Lomas DJ, Cochran EK, Gorden P, O'Rahilly S, Savage DB. Semple RK, et al. Among authors: sleigh a. J Clin Invest. 2009 Feb;119(2):315-22. doi: 10.1172/JCI37432. Epub 2009 Jan 26. J Clin Invest. 2009. PMID: 19164855 Free PMC article.
Mitochondrial dysfunction in patients with primary congenital insulin resistance.
Sleigh A, Raymond-Barker P, Thackray K, Porter D, Hatunic M, Vottero A, Burren C, Mitchell C, McIntyre M, Brage S, Carpenter TA, Murgatroyd PR, Brindle KM, Kemp GJ, O'Rahilly S, Semple RK, Savage DB. Sleigh A, et al. J Clin Invest. 2011 Jun;121(6):2457-61. doi: 10.1172/JCI46405. Epub 2011 May 9. J Clin Invest. 2011. PMID: 21555852 Free PMC article.
Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals.
Finucane FM, Sharp SJ, Hatunic M, Sleigh A, De Lucia Rolfe E, Sayer AA, Cooper C, Griffin SJ, Savage DB, Wareham NJ. Finucane FM, et al. Among authors: sleigh a. Int J Endocrinol. 2013;2013:870487. doi: 10.1155/2013/870487. Epub 2013 May 2. Int J Endocrinol. 2013. PMID: 23737780 Free PMC article.
Short-term administration of pegvisomant improves hepatic insulin sensitivity and reduces soleus muscle intramyocellular lipid content in young adults with type 1 diabetes.
Thankamony A, Tossavainen PH, Sleigh A, Acerini C, Elleri D, Dalton RN, Jackson NC, Umpleby AM, Williams RM, Dunger DB. Thankamony A, et al. Among authors: sleigh a. J Clin Endocrinol Metab. 2014 Feb;99(2):639-47. doi: 10.1210/jc.2013-3264. Epub 2013 Dec 11. J Clin Endocrinol Metab. 2014. PMID: 24423298 Clinical Trial.
Low circulating levels of IGF-1 in healthy adults are associated with reduced β-cell function, increased intramyocellular lipid, and enhanced fat utilization during fasting.
Thankamony A, Capalbo D, Marcovecchio ML, Sleigh A, Jørgensen SW, Hill NR, Mooslehner K, Yeo GS, Bluck L, Juul A, Vaag A, Dunger DB. Thankamony A, et al. Among authors: sleigh a. J Clin Endocrinol Metab. 2014 Jun;99(6):2198-207. doi: 10.1210/jc.2013-4542. Epub 2014 Mar 11. J Clin Endocrinol Metab. 2014. PMID: 24617714 Free PMC article.
Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations.
Huang-Doran I, Tomlinson P, Payne F, Gast A, Sleigh A, Bottomley W, Harris J, Daly A, Rocha N, Rudge S, Clark J, Kwok A, Romeo S, McCann E, Müksch B, Dattani M, Zucchini S, Wakelam M, Foukas LC, Savage DB, Murphy R, O'Rahilly S, Barroso I, Semple RK. Huang-Doran I, et al. Among authors: sleigh a. JCI Insight. 2016 Oct 20;1(17):e88766. doi: 10.1172/jci.insight.88766. JCI Insight. 2016. PMID: 27766312 Free PMC article.
250 results