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RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.
Patel PS, Abraham KJ, Guturi KKN, Halaby MJ, Khan Z, Palomero L, Ho B, Duan S, St-Germain J, Algouneh A, Mateo F, El Ghamrasni S, Barbour H, Barnes DR, Beesley J, Sanchez O, Berman HK, Brown GW, Affar EB, Chenevix-Trench G, Antoniou AC, Arrowsmith CH, Raught B, Pujana MA, Mekhail K, Hakem A, Hakem R. Patel PS, et al. Among authors: abraham kj. J Clin Invest. 2021 Feb 1;131(3):e140105. doi: 10.1172/JCI140105. J Clin Invest. 2021. PMID: 33529165 Free PMC article.
Non-coding RNA in neural function, disease, and aging.
Szafranski K, Abraham KJ, Mekhail K. Szafranski K, et al. Among authors: abraham kj. Front Genet. 2015 Mar 9;6:87. doi: 10.3389/fgene.2015.00087. eCollection 2015. Front Genet. 2015. PMID: 25806046 Free PMC article. Review.
Nucleolar RNA polymerase II drives ribosome biogenesis.
Abraham KJ, Khosraviani N, Chan JNY, Gorthi A, Samman A, Zhao DY, Wang M, Bokros M, Vidya E, Ostrowski LA, Oshidari R, Pietrobon V, Patel PS, Algouneh A, Singhania R, Liu Y, Yerlici VT, De Carvalho DD, Ohh M, Dickson BC, Hakem R, Greenblatt JF, Lee S, Bishop AJR, Mekhail K. Abraham KJ, et al. Nature. 2020 Sep;585(7824):298-302. doi: 10.1038/s41586-020-2497-0. Epub 2020 Jul 15. Nature. 2020. PMID: 32669707 Free PMC article.
Conserved Pbp1/Ataxin-2 regulates retrotransposon activity and connects polyglutamine expansion-driven protein aggregation to lifespan-controlling rDNA repeats.
Ostrowski LA, Hall AC, Szafranski KJ, Oshidari R, Abraham KJ, Chan JNY, Krustev C, Zhang K, Wang A, Liu Y, Guo R, Mekhail K. Ostrowski LA, et al. Among authors: abraham kj. Commun Biol. 2018 Nov 5;1:187. doi: 10.1038/s42003-018-0187-3. eCollection 2018. Commun Biol. 2018. PMID: 30417124 Free PMC article.
A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.
Liu Y, Iqbal A, Li W, Ni Z, Wang Y, Ramprasad J, Abraham KJ, Zhang M, Zhao DY, Qin S, Loppnau P, Jiang H, Guo X, Brown PJ, Zhen X, Xu G, Mekhail K, Ji X, Bedford MT, Greenblatt JF, Min J. Liu Y, et al. Among authors: abraham kj. Nat Commun. 2022 Sep 16;13(1):5453. doi: 10.1038/s41467-022-33229-5. Nat Commun. 2022. PMID: 36114190 Free PMC article.
30 results