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The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID.
Safavi S, Larouche A, Zahn A, Patenaude AM, Domanska D, Dionne K, Rognes T, Dingler F, Kang SK, Liu Y, Johnson N, Hébert J, Verdun RE, Rada CA, Vega F, Nilsen H, Di Noia JM. Safavi S, et al. Among authors: zahn a. NAR Cancer. 2020 Aug 27;2(3):zcaa019. doi: 10.1093/narcan/zcaa019. eCollection 2020 Sep. NAR Cancer. 2020. PMID: 33554121 Free PMC article.
HSP90 inhibitors decrease AID levels and activity in mice and in human cells.
Montamat-Sicotte D, Litzler LC, Abreu C, Safavi S, Zahn A, Orthwein A, Müschen M, Oppezzo P, Muñoz DP, Di Noia JM. Montamat-Sicotte D, et al. Among authors: zahn a. Eur J Immunol. 2015 Aug;45(8):2365-76. doi: 10.1002/eji.201545462. Epub 2015 May 18. Eur J Immunol. 2015. PMID: 25912253 Free PMC article.
UNG protects B cells from AID-induced telomere loss.
Cortizas EM, Zahn A, Safavi S, Reed JA, Vega F, Di Noia JM, Verdun RE. Cortizas EM, et al. Among authors: zahn a. J Exp Med. 2016 Oct 17;213(11):2459-2472. doi: 10.1084/jem.20160635. Epub 2016 Oct 3. J Exp Med. 2016. PMID: 27697833 Free PMC article.
PRMT5 is essential for B cell development and germinal center dynamics.
Litzler LC, Zahn A, Meli AP, Hébert S, Patenaude AM, Methot SP, Sprumont A, Bois T, Kitamura D, Costantino S, King IL, Kleinman CL, Richard S, Di Noia JM. Litzler LC, et al. Among authors: zahn a. Nat Commun. 2019 Jan 3;10(1):22. doi: 10.1038/s41467-018-07884-6. Nat Commun. 2019. PMID: 30604754 Free PMC article.
98 results