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Excessive O-GlcNAcylation Causes Heart Failure and Sudden Death.
Umapathi P, Mesubi OO, Banerjee PS, Abrol N, Wang Q, Luczak ED, Wu Y, Granger JM, Wei AC, Reyes Gaido OE, Florea L, Talbot CC Jr, Hart GW, Zachara NE, Anderson ME. Umapathi P, et al. Among authors: florea l. Circulation. 2021 Apr 27;143(17):1687-1703. doi: 10.1161/CIRCULATIONAHA.120.051911. Epub 2021 Feb 17. Circulation. 2021. PMID: 33593071 Free PMC article.
ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation.
Gable DL, Gaysinskaya V, Atik CC, Talbot CC Jr, Kang B, Stanley SE, Pugh EW, Amat-Codina N, Schenk KM, Arcasoy MO, Brayton C, Florea L, Armanios M. Gable DL, et al. Among authors: florea l. Genes Dev. 2019 Oct 1;33(19-20):1381-1396. doi: 10.1101/gad.326785.119. Epub 2019 Sep 5. Genes Dev. 2019. PMID: 31488579 Free PMC article.
CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution.
Wang Q, Hernández-Ochoa EO, Viswanathan MC, Blum ID, Do DC, Granger JM, Murphy KR, Wei AC, Aja S, Liu N, Antonescu CM, Florea LD, Talbot CC Jr, Mohr D, Wagner KR, Regot S, Lovering RM, Gao P, Bianchet MA, Wu MN, Cammarato A, Schneider MF, Bever GS, Anderson ME. Wang Q, et al. Nat Commun. 2021 May 26;12(1):3175. doi: 10.1038/s41467-021-23549-3. Nat Commun. 2021. PMID: 34039988 Free PMC article.
Interleukin-6 Drives Mitochondrial Dysregulation and Accelerates Physical Decline: Insights From an Inducible Humanized IL-6 Knock-In Mouse Model.
Nidadavolu LS, Cosarderelioglu C, Merino Gomez A, Wu Y, Bopp T, Zhang C, Nguyen T, Marx-Rattner R, Yang H, Antonescu C, Florea L, Talbot CC, Smith B, Foster DB, Fairman JE, Yenokyan G, Chung T, Le A, Walston JD, Abadir PM. Nidadavolu LS, et al. Among authors: florea l. J Gerontol A Biol Sci Med Sci. 2023 Oct 9;78(10):1740-1752. doi: 10.1093/gerona/glad147. J Gerontol A Biol Sci Med Sci. 2023. PMID: 37310873
A non-mosaic transchromosomic mouse model of down syndrome carrying the long arm of human chromosome 21.
Kazuki Y, Gao FJ, Li Y, Moyer AJ, Devenney B, Hiramatsu K, Miyagawa-Tomita S, Abe S, Kazuki K, Kajitani N, Uno N, Takehara S, Takiguchi M, Yamakawa M, Hasegawa A, Shimizu R, Matsukura S, Noda N, Ogonuki N, Inoue K, Matoba S, Ogura A, Florea LD, Savonenko A, Xiao M, Wu D, Batista DA, Yang J, Qiu Z, Singh N, Richtsmeier JT, Takeuchi T, Oshimura M, Reeves RH. Kazuki Y, et al. Elife. 2020 Jun 29;9:e56223. doi: 10.7554/eLife.56223. Elife. 2020. PMID: 32597754 Free PMC article.
Germline Mutations in DNA Repair Genes in Lung Adenocarcinoma.
Parry EM, Gable DL, Stanley SE, Khalil SE, Antonescu V, Florea L, Armanios M. Parry EM, et al. Among authors: florea l. J Thorac Oncol. 2017 Nov;12(11):1673-1678. doi: 10.1016/j.jtho.2017.08.011. Epub 2017 Aug 24. J Thorac Oncol. 2017. PMID: 28843361 Free PMC article.
151 results