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Control of metabolism by p53 - Cancer and beyond.
Labuschagne CF, Zani F, Vousden KH. Labuschagne CF, et al. Among authors: zani f. Biochim Biophys Acta Rev Cancer. 2018 Aug;1870(1):32-42. doi: 10.1016/j.bbcan.2018.06.001. Epub 2018 Jun 5. Biochim Biophys Acta Rev Cancer. 2018. PMID: 29883595 Free PMC article. Review.
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.
Tajan M, Hennequart M, Cheung EC, Zani F, Hock AK, Legrave N, Maddocks ODK, Ridgway RA, Athineos D, Suárez-Bonnet A, Ludwig RL, Novellasdemunt L, Angelis N, Li VSW, Vlachogiannis G, Valeri N, Mainolfi N, Suri V, Friedman A, Manfredi M, Blyth K, Sansom OJ, Vousden KH. Tajan M, et al. Among authors: zani f. Nat Commun. 2021 Jan 14;12(1):366. doi: 10.1038/s41467-020-20223-y. Nat Commun. 2021. PMID: 33446657 Free PMC article.
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.
Blagih J, Zani F, Chakravarty P, Hennequart M, Pilley S, Hobor S, Hock AK, Walton JB, Morton JP, Gronroos E, Mason S, Yang M, McNeish I, Swanton C, Blyth K, Vousden KH. Blagih J, et al. Among authors: zani f. Cell Rep. 2020 Jan 14;30(2):481-496.e6. doi: 10.1016/j.celrep.2019.12.028. Cell Rep. 2020. PMID: 31940491 Free PMC article.
PI3Kγ ablation does not promote diabetes in db/db mice, but improves insulin sensitivity and reduces pancreatic β-cell apoptosis.
Breasson L, Sardi C, Becattini B, Zani F, Solinas G. Breasson L, et al. Among authors: zani f. FASEB J. 2018 Jan;32(1):319-329. doi: 10.1096/fj.201700372RR. Epub 2017 Sep 13. FASEB J. 2018. PMID: 28904022
We conclude that PI3Kgamma inhibition in obese patients who are predisposed to beta-cell failure is not expected to produce adverse effects on insulin secretion.-Breasson, L., Sardi, C., Becattini, B., Zani, F., Solinas, G. PI3Kgamma ablation does not promote diabet …
We conclude that PI3Kgamma inhibition in obese patients who are predisposed to beta-cell failure is not expected to produce adverse effects …
PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance.
Becattini B, Marone R, Zani F, Arsenijevic D, Seydoux J, Montani JP, Dulloo AG, Thorens B, Preitner F, Wymann MP, Solinas G. Becattini B, et al. Among authors: zani f. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):E854-63. doi: 10.1073/pnas.1106698108. Epub 2011 Sep 26. Proc Natl Acad Sci U S A. 2011. PMID: 21949398 Free PMC article.
JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage.
Becattini B, Zani F, Breasson L, Sardi C, D'Agostino VG, Choo MK, Provenzani A, Park JM, Solinas G. Becattini B, et al. Among authors: zani f. FASEB J. 2016 Sep;30(9):3124-32. doi: 10.1096/fj.201600393R. Epub 2016 May 26. FASEB J. 2016. PMID: 27230858 Free PMC article.
We conclude that compounds targeting JNK1 activity in brain and adipose tissue, which do not accumulate in the skin, may be safer and most effective.-Becattini, B., Zani, F., Breasson, L., Sardi, C., D'Agostino, V. G., Choo, M.-K., Provenzani, A., Park, J. ...
We conclude that compounds targeting JNK1 activity in brain and adipose tissue, which do not accumulate in the skin, may be safer and most e …
90 results