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Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off-label in the first wave of COVID-19.
Delaunois A, Abernathy M, Anderson WD, Beattie KA, Chaudhary KW, Coulot J, Gryshkova V, Hebeisen S, Holbrook M, Kramer J, Kuryshev Y, Leishman D, Lushbough I, Passini E, Redfern WS, Rodriguez B, Rossman EI, Trovato C, Wu C, Valentin JP. Delaunois A, et al. Among authors: passini e. Clin Transl Sci. 2021 May;14(3):1133-1146. doi: 10.1111/cts.13011. Epub 2021 Apr 9. Clin Transl Sci. 2021. PMID: 33620150 Free PMC article.
Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop.
Rodriguez B, Carusi A, Abi-Gerges N, Ariga R, Britton O, Bub G, Bueno-Orovio A, Burton RA, Carapella V, Cardone-Noott L, Daniels MJ, Davies MR, Dutta S, Ghetti A, Grau V, Harmer S, Kopljar I, Lambiase P, Lu HR, Lyon A, Minchole A, Muszkiewicz A, Oster J, Paci M, Passini E, Severi S, Taggart P, Tinker A, Valentin JP, Varro A, Wallman M, Zhou X. Rodriguez B, et al. Among authors: passini e. Europace. 2016 Sep;18(9):1287-98. doi: 10.1093/europace/euv320. Epub 2015 Nov 29. Europace. 2016. PMID: 26622055 Free PMC article.
General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.
Li Z, Mirams GR, Yoshinaga T, Ridder BJ, Han X, Chen JE, Stockbridge NL, Wisialowski TA, Damiano B, Severi S, Morissette P, Kowey PR, Holbrook M, Smith G, Rasmusson RL, Liu M, Song Z, Qu Z, Leishman DJ, Steidl-Nichols J, Rodriguez B, Bueno-Orovio A, Zhou X, Passini E, Edwards AG, Morotti S, Ni H, Grandi E, Clancy CE, Vandenberg J, Hill A, Nakamura M, Singer T, Polonchuk L, Greiter-Wilke A, Wang K, Nave S, Fullerton A, Sobie EA, Paci M, Musuamba Tshinanu F, Strauss DG. Li Z, et al. Among authors: passini e. Clin Pharmacol Ther. 2020 Jan;107(1):102-111. doi: 10.1002/cpt.1647. Epub 2019 Nov 10. Clin Pharmacol Ther. 2020. PMID: 31709525 Free PMC article.
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Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay.
Morissette P, Polak S, Chain A, Zhai J, Imredy JP, Wildey MJ, Travis J, Fitzgerald K, Fanelli P, Passini E, Rodriguez B, Sannajust F, Regan C. Morissette P, et al. Among authors: passini e. Toxicol Appl Pharmacol. 2020 Mar 1;390:114883. doi: 10.1016/j.taap.2020.114883. Epub 2020 Jan 23. Toxicol Appl Pharmacol. 2020. PMID: 31981640 Free PMC article.
48 results