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Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant.
Jiang H, Hooper C, Kelly M, Steeples V, Simon JN, Beglov J, Azad AJ, Leinhos L, Bennett P, Ehler E, Kalisch-Smith JI, Sparrow DB, Fischer R, Heilig R, Isackson H, Ehsan M, Patone G, Huebner N, Davies B, Watkins H, Gehmlich K. Jiang H, et al. Among authors: simon jn. Basic Res Cardiol. 2021 Feb 26;116(1):14. doi: 10.1007/s00395-021-00853-z. Basic Res Cardiol. 2021. PMID: 33637999 Free PMC article.
Comparing the effects of chemical Ca2+ dyes and R-GECO on contractility and Ca2+ transients in adult and human iPSC cardiomyocytes.
Robinson P, Sparrow AJ, Psaras Y, Steeples V, Simon JN, Broyles CN, Chang YF, Brook FA, Wang YJ, Blease A, Zhang X, Abassi YA, Geeves MA, Toepfer CN, Watkins H, Redwood C, Daniels MJ. Robinson P, et al. Among authors: simon jn. J Mol Cell Cardiol. 2023 Jul;180:44-57. doi: 10.1016/j.yjmcc.2023.04.008. Epub 2023 Apr 29. J Mol Cell Cardiol. 2023. PMID: 37127261 Free PMC article.
BH4 Increases nNOS Activity and Preserves Left Ventricular Function in Diabetes.
Carnicer R, Duglan D, Ziberna K, Recalde A, Reilly S, Simon JN, Mafrici S, Arya R, Roselló-Lletí E, Chuaiphichai S, Tyler D, Lygate CA, Channon KM, Casadei B. Carnicer R, et al. Among authors: simon jn. Circ Res. 2021 Mar 5;128(5):585-601. doi: 10.1161/CIRCRESAHA.120.316656. Epub 2021 Jan 26. Circ Res. 2021. PMID: 33494625 Free PMC article.
Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury.
Chuaiphichai S, Chu SM, Carnicer R, Kelly M, Bendall JK, Simon JN, Douglas G, Crabtree MJ, Casadei B, Channon KM. Chuaiphichai S, et al. Among authors: simon jn. Am J Physiol Heart Circ Physiol. 2023 Apr 1;324(4):H430-H442. doi: 10.1152/ajpheart.00562.2022. Epub 2023 Feb 3. Am J Physiol Heart Circ Physiol. 2023. PMID: 36735402 Free PMC article.
Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine.
Faller KME, Atzler D, McAndrew DJ, Zervou S, Whittington HJ, Simon JN, Aksentijevic D, Ten Hove M, Choe CU, Isbrandt D, Casadei B, Schneider JE, Neubauer S, Lygate CA. Faller KME, et al. Among authors: simon jn. Cardiovasc Res. 2018 Mar 1;114(3):417-430. doi: 10.1093/cvr/cvx242. Cardiovasc Res. 2018. PMID: 29236952 Free PMC article.
23 results