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Page 1
Oncogenic KIT Modulates Type I IFN-Mediated Antitumor Immunity in GIST.
Liu M, Etherington MS, Hanna A, Medina BD, Vitiello GA, Bowler TG, Param NJ, Levin L, Rossi F, DeMatteo RP. Liu M, et al. Among authors: dematteo rp. Cancer Immunol Res. 2021 May;9(5):542-553. doi: 10.1158/2326-6066.CIR-20-0692. Epub 2021 Mar 1. Cancer Immunol Res. 2021. PMID: 33648985 Free PMC article.
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido.
Balachandran VP, Cavnar MJ, Zeng S, Bamboat ZM, Ocuin LM, Obaid H, Sorenson EC, Popow R, Ariyan C, Rossi F, Besmer P, Guo T, Antonescu CR, Taguchi T, Yuan J, Wolchok JD, Allison JP, DeMatteo RP. Balachandran VP, et al. Among authors: dematteo rp. Nat Med. 2011 Aug 28;17(9):1094-100. doi: 10.1038/nm.2438. Nat Med. 2011. PMID: 21873989 Free PMC article.
KIT oncogene inhibition drives intratumoral macrophage M2 polarization.
Cavnar MJ, Zeng S, Kim TS, Sorenson EC, Ocuin LM, Balachandran VP, Seifert AM, Greer JB, Popow R, Crawley MH, Cohen NA, Green BL, Rossi F, Besmer P, Antonescu CR, DeMatteo RP. Cavnar MJ, et al. Among authors: dematteo rp. J Exp Med. 2013 Dec 16;210(13):2873-86. doi: 10.1084/jem.20130875. Epub 2013 Dec 9. J Exp Med. 2013. PMID: 24323358 Free PMC article.
Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor.
Kim TS, Cavnar MJ, Cohen NA, Sorenson EC, Greer JB, Seifert AM, Crawley MH, Green BL, Popow R, Pillarsetty N, Veach DR, Ku AT, Rossi F, Besmer P, Antonescu CR, Zeng S, Dematteo RP. Kim TS, et al. Among authors: dematteo rp. Clin Cancer Res. 2014 May 1;20(9):2350-62. doi: 10.1158/1078-0432.CCR-13-3033. Epub 2014 Feb 28. Clin Cancer Res. 2014. PMID: 24583793 Free PMC article.
Pharmacological Inhibition of KIT Activates MET Signaling in Gastrointestinal Stromal Tumors.
Cohen NA, Zeng S, Seifert AM, Kim TS, Sorenson EC, Greer JB, Beckman MJ, Santamaria-Barria JA, Crawley MH, Green BL, Rossi F, Besmer P, Antonescu CR, DeMatteo RP. Cohen NA, et al. Among authors: dematteo rp. Cancer Res. 2015 May 15;75(10):2061-70. doi: 10.1158/0008-5472.CAN-14-2564. Epub 2015 Apr 2. Cancer Res. 2015. PMID: 25836719 Free PMC article.
PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors.
Seifert AM, Zeng S, Zhang JQ, Kim TS, Cohen NA, Beckman MJ, Medina BD, Maltbaek JH, Loo JK, Crawley MH, Rossi F, Besmer P, Antonescu CR, DeMatteo RP. Seifert AM, et al. Among authors: dematteo rp. Clin Cancer Res. 2017 Jan 15;23(2):454-465. doi: 10.1158/1078-0432.CCR-16-1163. Epub 2016 Jul 28. Clin Cancer Res. 2017. PMID: 27470968 Free PMC article.
Combined KIT and CTLA-4 Blockade in Patients with Refractory GIST and Other Advanced Sarcomas: A Phase Ib Study of Dasatinib plus Ipilimumab.
D'Angelo SP, Shoushtari AN, Keohan ML, Dickson MA, Gounder MM, Chi P, Loo JK, Gaffney L, Schneider L, Patel Z, Erinjeri JP, Bluth MJ, Sjoberg A, Streicher H, Takebe N, Qin LX, Antonescu C, DeMatteo RP, Carvajal RD, Tap WD. D'Angelo SP, et al. Among authors: dematteo rp. Clin Cancer Res. 2017 Jun 15;23(12):2972-2980. doi: 10.1158/1078-0432.CCR-16-2349. Epub 2016 Dec 22. Clin Cancer Res. 2017. PMID: 28007774 Free PMC article. Clinical Trial.
Wnt/β-catenin Signaling Contributes to Tumor Malignancy and Is Targetable in Gastrointestinal Stromal Tumor.
Zeng S, Seifert AM, Zhang JQ, Cavnar MJ, Kim TS, Balachandran VP, Santamaria-Barria JA, Cohen NA, Beckman MJ, Medina BD, Rossi F, Crawley MH, Loo JK, Maltbaek JH, Besmer P, Antonescu CR, DeMatteo RP. Zeng S, et al. Among authors: dematteo rp. Mol Cancer Ther. 2017 Sep;16(9):1954-1966. doi: 10.1158/1535-7163.MCT-17-0139. Epub 2017 Jun 13. Mol Cancer Ther. 2017. PMID: 28611108 Free PMC article.
Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor.
Bosbach B, Rossi F, Yozgat Y, Loo J, Zhang JQ, Berrozpe G, Warpinski K, Ehlers I, Veach D, Kwok A, Manova K, Antonescu CR, DeMatteo RP, Besmer P. Bosbach B, et al. Among authors: dematteo rp. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8448-E8457. doi: 10.1073/pnas.1711449114. Epub 2017 Sep 18. Proc Natl Acad Sci U S A. 2017. PMID: 28923937 Free PMC article.
525 results