Zhang W - Search Results

1

Strategies for delivering therapeutics across the blood-brain barrier.

Terstappen GC, Meyer AH, Bell RD, Zhang W. Terstappen GC, et al. Among authors: zhang w. Nat Rev Drug Discov. 2021 May;20(5):362-383. doi: 10.1038/s41573-021-00139-y. Epub 2021 Mar 1. Nat Rev Drug Discov. 2021. PMID: 33649582 Review.

2

ABC transporters and drug efflux at the blood-brain barrier.

Shen S, Zhang W. Shen S, et al. Among authors: zhang w. Rev Neurosci. 2010;21(1):29-53. doi: 10.1515/revneuro.2010.21.1.29. Rev Neurosci. 2010. PMID: 20458886 Review.

3

Quantitative Algorithm-Based Paired Imaging Measurement for Antibody-Triggered Endocytosis in Cultured Cells.

Gong S, Li Y, Su W, Ding Y, Lu J, Dong K, Hood S, Zhang W, Terstappen GC. Gong S, et al. Among authors: zhang w. SLAS Discov. 2018 Sep;23(8):832-841. doi: 10.1177/2472555218761355. Epub 2018 Mar 5. SLAS Discov. 2018. PMID: 29505735 Free article.

4

Drug Distribution into Peripheral Nerve.

Liu H, Chen Y, Huang L, Sun X, Fu T, Wu S, Zhu X, Zhen W, Liu J, Lu G, Cai W, Yang T, Zhang W, Yu X, Wan Z, Wang J, Summerfield SG, Dong K, Terstappen GC. Liu H, et al. Among authors: zhang w. J Pharmacol Exp Ther. 2018 May;365(2):336-345. doi: 10.1124/jpet.117.245613. Epub 2018 Mar 6. J Pharmacol Exp Ther. 2018. PMID: 29511033

5

Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems.

Liu H, Dong K, Zhang W, Summerfield SG, Terstappen GC. Liu H, et al. Among authors: zhang w. Drug Discov Today. 2018 Jul;23(7):1357-1372. doi: 10.1016/j.drudis.2018.03.002. Epub 2018 Mar 13. Drug Discov Today. 2018. PMID: 29548981 Review.

6

Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs.

Li Y, Sun X, Liu H, Huang L, Meng G, Ding Y, Su W, Lu J, Gong S, Terstappen GC, Zhang R, Zhang W. Li Y, et al. Among authors: zhang r, zhang w. Neurosci Bull. 2019 Dec;35(6):996-1010. doi: 10.1007/s12264-019-00384-7. Epub 2019 May 11. Neurosci Bull. 2019. PMID: 31079318 Free PMC article.

7

Differentiation of Human Induced Pluripotent Stem Cells (hiPSC) into Endothelial-Type Cells and Establishment of an In Vitro Blood-Brain Barrier Model.

Li Y, Terstappen GC, Zhang W. Li Y, et al. Among authors: zhang w. Methods Mol Biol. 2022;2454:521-530. doi: 10.1007/7651_2021_363. Methods Mol Biol. 2022. PMID: 33689164

8

Indomethacin and cyclosporin a inhibit in vitro ischemia-induced expression of ICAM-1 and chemokines in human brain endothelial cells.

Zhang W, Smith C, Monette R, Hutchison J, Stanimirovic DB. Zhang W, et al. Acta Neurochir Suppl. 2000;76:47-53. doi: 10.1007/978-3-7091-6346-7_10. Acta Neurochir Suppl. 2000. PMID: 11450070

9

ABCG2 is upregulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Abeta(1-40) peptides.

Xiong H, Callaghan D, Jones A, Bai J, Rasquinha I, Smith C, Pei K, Walker D, Lue LF, Stanimirovic D, Zhang W. Xiong H, et al. Among authors: zhang w. J Neurosci. 2009 Apr 29;29(17):5463-75. doi: 10.1523/JNEUROSCI.5103-08.2009. J Neurosci. 2009. PMID: 19403814 Free PMC article.

10

Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human.

Zhang W, Liu QY, Haqqani AS, Leclerc S, Liu Z, Fauteux F, Baumann E, Delaney CE, Ly D, Star AT, Brunette E, Sodja C, Hewitt M, Sandhu JK, Stanimirovic DB. Zhang W, et al. Fluids Barriers CNS. 2020 Jul 22;17(1):47. doi: 10.1186/s12987-020-00209-0. Fluids Barriers CNS. 2020. PMID: 32698806 Free PMC article.

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