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Role of Vasoactive Hormone-Induced Signal Transduction in Cardiac Hypertrophy and Heart Failure.
Dhalla NS, Mota KO, Elimban V, Shah AK, de Vasconcelos CML, Bhullar SK. Dhalla NS, et al. Cells. 2024 May 17;13(10):856. doi: 10.3390/cells13100856. Cells. 2024. PMID: 38786079 Review.
The prolonged exposure of the hypertrophied heart to these vasoactive hormones has been reported to result in the oxidation of catecholamines and serotonin via monoamine oxidase as well as the activation of NADPH oxidase via angiotensin II and endothelins to …
The prolonged exposure of the hypertrophied heart to these vasoactive hormones has been reported to result in the oxidation of catecholamine …
Construction of Multi-enzyme Integrated Catalysts for Deracemization of Cyclic Chiral Amines.
Zhou L, Li C, Dong L, Liu Y, He Y, Liu G, Bai J, Ma L, Jiang Y. Zhou L, et al. Chembiochem. 2024 May 22:e202400346. doi: 10.1002/cbic.202400346. Online ahead of print. Chembiochem. 2024. PMID: 38775416
In this research, we designed a four-enzyme integrated catalyst and used it to catalyse the racemization reaction of cyclic chiral amines, where monoamine oxidase (MAO) catalyses the selective oxidation of 1-methyl-1,2,3,4-tetrahydroisoquinoline (MTQ), imine reducta …
In this research, we designed a four-enzyme integrated catalyst and used it to catalyse the racemization reaction of cyclic chiral amines, w …
5,7-dihydroxy-3',4',5'-trimethoxyflavone mitigates lead induced neurotoxicity in rats via its chelating, antioxidant, anti-inflammatory and monoaminergic properties.
Singh V, Shri R, Sood P, Singh M, Singh TG, Singh R, Kumar A, Ahmad SF. Singh V, et al. Food Chem Toxicol. 2024 May 18;189:114747. doi: 10.1016/j.fct.2024.114747. Online ahead of print. Food Chem Toxicol. 2024. PMID: 38768937
Cognitive and motor functions were assessed using Morris Water Maze and horizontal bar tests. Lead, monoamine oxidase (MAO) A and B enzymes, reduced glutathione (GSH), thiobarbituric acid reactive species (TBARS), Tumor necrosis factor-alpha (TNF-alpha …
Cognitive and motor functions were assessed using Morris Water Maze and horizontal bar tests. Lead, monoamine oxidase (MAO …
Novel biaryloxazolidinone derivatives with broad-spectrum antibacterial activity, favorable drug-like profiles and in vivo efficacy against linezolid-resistant Staphylococcusaureus.
Duan M, Qiu C, Huang X, Sun L, He X, Wang Z, Yue H, Wang K, Qi Y, Peng S, Shi X, Xi Z, Tong M, Ding X, Hou Y, Zhao Y. Duan M, et al. Eur J Med Chem. 2024 May 17;273:116493. doi: 10.1016/j.ejmech.2024.116493. Online ahead of print. Eur J Med Chem. 2024. PMID: 38761790
Compound 8b was demonstrated as a promising candidate through druglikeness evaluation including metabolism in microsomes and plasma, Caco-2 cell permeability, plasma protein binding, cytotoxicity, and inhibition of CYP450 and human monoamine oxidase. Notably, compou …
Compound 8b was demonstrated as a promising candidate through druglikeness evaluation including metabolism in microsomes and plasma, Caco-2 …
Tonic excitation by astrocytic GABA causes neuropathic pain by augmenting neuronal activity and glucose metabolism.
Ju YH, Cho J, Park JY, Kim H, Hong EB, Lee CJ, Chung E, Kim HI, Nam MH. Ju YH, et al. Exp Mol Med. 2024 May 17. doi: 10.1038/s12276-024-01232-z. Online ahead of print. Exp Mol Med. 2024. PMID: 38760512 Free article.
Using multiple electrophysiological methods, we demonstrated that neuronal hyperexcitability is attributed to both increased astrocytic GABA synthesis via monoamine oxidase B (MAOB) and the depolarized reversal potential of GABA-mediated currents (E(GABA)) via the d …
Using multiple electrophysiological methods, we demonstrated that neuronal hyperexcitability is attributed to both increased astrocytic GABA …
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones.
Castillo-Arellano JI, Stryker Z, Wyatt MD, León F. Castillo-Arellano JI, et al. ACS Med Chem Lett. 2024 Apr 3;15(5):610-618. doi: 10.1021/acsmedchemlett.3c00573. eCollection 2024 May 9. ACS Med Chem Lett. 2024. PMID: 38746894
Small molecule neurotransmitters containing amines are metabolized by monoamine oxidase (MAO) in the nervous system. Monoamine oxidase inhibitors are a valuable class of drugs prescribed for the management of neurological disorders, including depressio …
Small molecule neurotransmitters containing amines are metabolized by monoamine oxidase (MAO) in the nervous system. Monoam …
In vitro and in vivo metabolism of psilocybin's active metabolite psilocin.
Thomann J, Kolaczynska KE, Stoeckmann OV, Rudin D, Vizeli P, Hoener MC, Pryce CR, Vollenweider FX, Liechti ME, Duthaler U. Thomann J, et al. Front Pharmacol. 2024 Apr 29;15:1391689. doi: 10.3389/fphar.2024.1391689. eCollection 2024. Front Pharmacol. 2024. PMID: 38741590 Free PMC article.
Metabolism studies were performed using human liver microsomes (HLM), cytochrome P450 (CYP) enzymes, monoamine oxidase (MAO), and UDP-glucuronosyltransferase (UGT). In vivo, metabolism was examined using male C57BL/6J mice and human plasma samples. ...However, the C …
Metabolism studies were performed using human liver microsomes (HLM), cytochrome P450 (CYP) enzymes, monoamine oxidase (MAO), …
Dihydroxanthene-based monoamine oxidase A-activated photosensitizers for photodynamic/photothermal therapy of tumors.
Mo Q, Zhong T, Cao B, Han Z, Hu X, Zhao S, Wei X, Yang Z, Qin J. Mo Q, et al. Eur J Med Chem. 2024 May 3;272:116474. doi: 10.1016/j.ejmech.2024.116474. Online ahead of print. Eur J Med Chem. 2024. PMID: 38735149
Small molecule photosensitizers for combined in vivo tailored cancer diagnostics and photodynamic/photothermal therapy are desperately needed. Monoamine oxidase A (MAO-A)-activated therapeutic and diagnostic compounds provide great selectivity because …
Small molecule photosensitizers for combined in vivo tailored cancer diagnostics and photodynamic/photothermal therapy are desperately neede …
26,205 results
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