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Metabolomics of sebum reveals lipid dysregulation in Parkinson's disease.
Sinclair E, Trivedi DK, Sarkar D, Walton-Doyle C, Milne J, Kunath T, Rijs AM, de Bie RMA, Goodacre R, Silverdale M, Barran P. Sinclair E, et al. Among authors: kunath t. Nat Commun. 2021 Mar 11;12(1):1592. doi: 10.1038/s41467-021-21669-4. Nat Commun. 2021. PMID: 33707447 Free PMC article.
Conformational dynamics of α-synuclein: insights from mass spectrometry.
Phillips AS, Gomes AF, Kalapothakis JM, Gillam JE, Gasparavicius J, Gozzo FC, Kunath T, MacPhee C, Barran PE. Phillips AS, et al. Among authors: kunath t. Analyst. 2015 May 7;140(9):3070-81. doi: 10.1039/c4an02306d. Epub 2015 Mar 10. Analyst. 2015. PMID: 25756329
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
Ludtmann MHR, Angelova PR, Horrocks MH, Choi ML, Rodrigues M, Baev AY, Berezhnov AV, Yao Z, Little D, Banushi B, Al-Menhali AS, Ranasinghe RT, Whiten DR, Yapom R, Dolt KS, Devine MJ, Gissen P, Kunath T, Jaganjac M, Pavlov EV, Klenerman D, Abramov AY, Gandhi S. Ludtmann MHR, et al. Among authors: kunath t. Nat Commun. 2018 Jun 12;9(1):2293. doi: 10.1038/s41467-018-04422-2. Nat Commun. 2018. PMID: 29895861 Free PMC article.
Discovery of Volatile Biomarkers of Parkinson's Disease from Sebum.
Trivedi DK, Sinclair E, Xu Y, Sarkar D, Walton-Doyle C, Liscio C, Banks P, Milne J, Silverdale M, Kunath T, Goodacre R, Barran P. Trivedi DK, et al. Among authors: kunath t. ACS Cent Sci. 2019 Apr 24;5(4):599-606. doi: 10.1021/acscentsci.8b00879. Epub 2019 Mar 20. ACS Cent Sci. 2019. PMID: 31041379 Free PMC article.
Validating Differential Volatilome Profiles in Parkinson's Disease.
Sinclair E, Walton-Doyle C, Sarkar D, Hollywood KA, Milne J, Lim SH, Kunath T, Rijs AM, de Bie RMA, Silverdale M, Trivedi DK, Barran P. Sinclair E, et al. Among authors: kunath t. ACS Cent Sci. 2021 Feb 24;7(2):300-306. doi: 10.1021/acscentsci.0c01028. Epub 2021 Feb 12. ACS Cent Sci. 2021. PMID: 33655068 Free PMC article.
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Choi ML, Chappard A, Singh BP, Maclachlan C, Rodrigues M, Fedotova EI, Berezhnov AV, De S, Peddie CJ, Athauda D, Virdi GS, Zhang W, Evans JR, Wernick AI, Zanjani ZS, Angelova PR, Esteras N, Vinokurov AY, Morris K, Jeacock K, Tosatto L, Little D, Gissen P, Clarke DJ, Kunath T, Collinson L, Klenerman D, Abramov AY, Horrocks MH, Gandhi S. Choi ML, et al. Among authors: kunath t. Nat Neurosci. 2022 Sep;25(9):1134-1148. doi: 10.1038/s41593-022-01140-3. Epub 2022 Aug 30. Nat Neurosci. 2022. PMID: 36042314 Free PMC article.
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons.
Virdi GS, Choi ML, Evans JR, Yao Z, Athauda D, Strohbuecker S, Nirujogi RS, Wernick AI, Pelegrina-Hidalgo N, Leighton C, Saleeb RS, Kopach O, Alrashidi H, Melandri D, Perez-Lloret J, Angelova PR, Sylantyev S, Eaton S, Heales S, Rusakov DA, Alessi DR, Kunath T, Horrocks MH, Abramov AY, Patani R, Gandhi S. Virdi GS, et al. Among authors: kunath t. NPJ Parkinsons Dis. 2022 Nov 24;8(1):162. doi: 10.1038/s41531-022-00423-7. NPJ Parkinsons Dis. 2022. PMID: 36424392 Free PMC article.
Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates.
Saleeb RS, Leighton C, Lee JE, O'Shaughnessy J, Jeacock K, Chappard A, Cumberland R, Zhao T, Ball SR, Sunde M, Clarke DJ, Piché K, McPhail JA, Louwrier A, Angers R, Gandhi S, Downey P, Kunath T, Horrocks MH. Saleeb RS, et al. Among authors: kunath t. Sci Adv. 2023 Nov 17;9(46):eadi7359. doi: 10.1126/sciadv.adi7359. Epub 2023 Nov 15. Sci Adv. 2023. PMID: 37967183 Free PMC article.
81 results