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Acute effect of inhaled iloprost on exercise dynamic hyperinflation in COPD patients: A randomized crossover study.
Lammi MR, Ghonim MA, Johnson J, D'Aquin J, Zamjahn JB, Pellett A, Okpechi SC, Romaine C, Pyakurel K, Luu HH, Shellito JE, Boulares AH, deBoisblanc BP. Lammi MR, et al. Among authors: pyakurel k. Respir Med. 2021 Apr-May;180:106354. doi: 10.1016/j.rmed.2021.106354. Epub 2021 Mar 8. Respir Med. 2021. PMID: 33721696 Free PMC article. Clinical Trial.
Treatment with intranasal iloprost reduces disease manifestations in a murine model of previously established COPD.
Lammi MR, Ghonim MA, Pyakurel K, Naura AS, Ibba SV, Davis CJ, Okpechi SC, Happel KI, deBoisblanc BP, Shellito J, Boulares AH. Lammi MR, et al. Among authors: pyakurel k. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 1;310(7):L630-8. doi: 10.1152/ajplung.00297.2015. Epub 2016 Feb 5. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 26851260 Free PMC article.
DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4⁺ T-cell function without causing severe combined immunodeficiency.
Ghonim MA, Pyakurel K, Ju J, Rodriguez PC, Lammi MR, Davis C, Abughazleh MQ, Mansy MS, Naura AS, Boulares AH. Ghonim MA, et al. Among authors: pyakurel k. J Allergy Clin Immunol. 2015 Feb;135(2):425-40. doi: 10.1016/j.jaci.2014.09.005. Epub 2014 Oct 19. J Allergy Clin Immunol. 2015. PMID: 25441643 Free PMC article.
PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice.
Ghonim MA, Pyakurel K, Ibba SV, Wang J, Rodriguez P, Al-Khami AA, Lammi MR, Kim H, Zea AH, Davis C, Okpechi S, Wyczechowska D, Al-Ghareeb K, Mansy MS, Ochoa A, Naura AS, Boulares AH. Ghonim MA, et al. Among authors: pyakurel k. Clin Sci (Lond). 2015 Dec;129(11):951-62. doi: 10.1042/CS20150122. Epub 2015 Jul 23. Clin Sci (Lond). 2015. PMID: 26205779 Free PMC article.
Fuelling the mechanisms of asthma: Increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target.
Al-Khami AA, Ghonim MA, Del Valle L, Ibba SV, Zheng L, Pyakurel K, Okpechi SC, Garay J, Wyczechowska D, Sanchez-Pino MD, Rodriguez PC, Boulares AH, Ochoa AC. Al-Khami AA, et al. Among authors: pyakurel k. Clin Exp Allergy. 2017 Sep;47(9):1170-1184. doi: 10.1111/cea.12947. Epub 2017 Jul 5. Clin Exp Allergy. 2017. PMID: 28456994 Free PMC article.
Minocycline blocks asthma-associated inflammation in part by interfering with the T cell receptor-nuclear factor κB-GATA-3-IL-4 axis without a prominent effect on poly(ADP-ribose) polymerase.
Naura AS, Kim H, Ju J, Rodriguez PC, Jordan J, Catling AD, Rezk BM, Abd Elmageed ZY, Pyakurel K, Tarhuni AF, Abughazleh MQ, Errami Y, Zerfaoui M, Ochoa AC, Boulares AH. Naura AS, et al. Among authors: pyakurel k. J Biol Chem. 2013 Jan 18;288(3):1458-68. doi: 10.1074/jbc.M112.419580. Epub 2012 Nov 26. J Biol Chem. 2013. PMID: 23184953 Free PMC article.
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