Young P - Search Results

1

Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion.

Cockerill GS, Angell RM, Bedernjak A, Chuckowree I, Fraser I, Gascon-Simorte J, Gilman MSA, Good JAD, Harland R, Johnson SM, Ludes-Meyers JH, Littler E, Lumley J, Lunn G, Mathews N, McLellan JS, Paradowski M, Peeples ME, Scott C, Tait D, Taylor G, Thom M, Thomas E, Villalonga Barber C, Ward SE, Watterson D, Williams G, Young P, Powell K. Cockerill GS, et al. Among authors: young p. J Med Chem. 2021 Apr 8;64(7):3658-3676. doi: 10.1021/acs.jmedchem.0c01882. Epub 2021 Mar 17. J Med Chem. 2021. PMID: 33729773

2

Modular alpha-helical mimetics with antiviral activity against respiratory syncitial virus.

Shepherd NE, Hoang HN, Desai VS, Letouze E, Young PR, Fairlie DP. Shepherd NE, et al. Among authors: young pr. J Am Chem Soc. 2006 Oct 11;128(40):13284-9. doi: 10.1021/ja064058a. J Am Chem Soc. 2006. PMID: 17017810

3

Potent cationic inhibitors of West Nile virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity.

Stoermer MJ, Chappell KJ, Liebscher S, Jensen CM, Gan CH, Gupta PK, Xu WJ, Young PR, Fairlie DP. Stoermer MJ, et al. Among authors: young pr. J Med Chem. 2008 Sep 25;51(18):5714-21. doi: 10.1021/jm800503y. Epub 2008 Aug 26. J Med Chem. 2008. PMID: 18729351

4

West Nile Virus NS2B/NS3 protease as an antiviral target.

Chappell KJ, Stoermer MJ, Fairlie DP, Young PR. Chappell KJ, et al. Among authors: young pr. Curr Med Chem. 2008;15(27):2771-84. doi: 10.2174/092986708786242804. Curr Med Chem. 2008. PMID: 18991636 Review.

5

Residues in domain III of the dengue virus envelope glycoprotein involved in cell-surface glycosaminoglycan binding.

Watterson D, Kobe B, Young PR. Watterson D, et al. J Gen Virol. 2012 Jan;93(Pt 1):72-82. doi: 10.1099/vir.0.037317-0. Epub 2011 Sep 28. J Gen Virol. 2012. PMID: 21957126

6

Evaluation of direct versus multi-layer passivation and capture chemistries for nanoparticle-based biosensor applications.

Sanjaya KC, Ranzoni A, Watterson D, Young P, Cooper MA. Sanjaya KC, et al. Among authors: young p. Biosens Bioelectron. 2015 May 15;67:769-74. doi: 10.1016/j.bios.2014.09.048. Epub 2014 Sep 28. Biosens Bioelectron. 2015. PMID: 25283448

7

Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity.

Modhiran N, Watterson D, Muller DA, Panetta AK, Sester DP, Liu L, Hume DA, Stacey KJ, Young PR. Modhiran N, et al. Among authors: young pr. Sci Transl Med. 2015 Sep 9;7(304):304ra142. doi: 10.1126/scitranslmed.aaa3863. Sci Transl Med. 2015. PMID: 26355031

8

Quantification of NS1 dengue biomarker in serum via optomagnetic nanocluster detection.

Antunes P, Watterson D, Parmvi M, Burger R, Boisen A, Young P, Cooper MA, Hansen MF, Ranzoni A, Donolato M. Antunes P, et al. Among authors: young p. Sci Rep. 2015 Nov 5;5:16145. doi: 10.1038/srep16145. Sci Rep. 2015. PMID: 26536916 Free PMC article.

9

Response to comment on "Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity" and "Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination".

Stacey KJ, Watterson D, Modhiran N, Young PR. Stacey KJ, et al. Sci Transl Med. 2015 Dec 16;7(318):318lr4. doi: 10.1126/scitranslmed.aad8657. Sci Transl Med. 2015. PMID: 26676606

10

The many faces of the flavivirus NS1 protein offer a multitude of options for inhibitor design.

Watterson D, Modhiran N, Young PR. Watterson D, et al. Antiviral Res. 2016 Jun;130:7-18. doi: 10.1016/j.antiviral.2016.02.014. Epub 2016 Mar 2. Antiviral Res. 2016. PMID: 26944216 Review.

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