Schalkwijk S - Search Results

1

Parent and Metabolite Concentration-QT Modeling to Evaluate QT-Interval Prolongation at Savolitinib Therapeutic Doses.

Schalkwijk S, Sahota T, Verheijen RB, Harmer AR, Ahmed GF. Schalkwijk S, et al. AAPS J. 2021 Mar 17;23(3):46. doi: 10.1208/s12248-021-00573-1. AAPS J. 2021. PMID: 33733338 Clinical Trial.

2

Concentration-QT modelling in early clinical oncology settings: Simulation evaluation of performance.

Cantet G, Berges A, O'Sullivan R, Cohen-Rabbie S, Dota C, Dubois V, Benoist GE, Tomkinson H, Rekić D, Parkinson J, Schalkwijk S. Cantet G, et al. Among authors: schalkwijk s. Br J Clin Pharmacol. 2022 Mar;88(3):1010-1019. doi: 10.1111/bcp.15047. Epub 2021 Sep 9. Br J Clin Pharmacol. 2022. PMID: 34416045 Free article.

3

Population pharmacokinetics and exposure-response of selumetinib and its N-desmethyl metabolite in pediatric patients with neurofibromatosis type 1 and inoperable plexiform neurofibromas.

Schalkwijk S, Zhou L, Cohen-Rabbie S, Jain L, Freshwater T, So K, He Z, Gioni I, Tomkinson H, Vishwanathan K, Zhou D. Schalkwijk S, et al. Cancer Chemother Pharmacol. 2021 Aug;88(2):189-202. doi: 10.1007/s00280-021-04274-6. Epub 2021 Apr 26. Cancer Chemother Pharmacol. 2021. PMID: 33903938

4

Clinical evaluation of the potential drug-drug interactions of savolitinib: Interaction with rifampicin, itraconazole, famotidine or midazolam.

Ren S, Vishwanathan K, Cantarini M, Frewer P, Hara I, Scarfe G, Burke W, Schalkwijk S, Li Y, Han D, Goldwater R. Ren S, et al. Among authors: schalkwijk s. Br J Clin Pharmacol. 2022 Feb;88(2):655-668. doi: 10.1111/bcp.14994. Epub 2021 Aug 21. Br J Clin Pharmacol. 2022. PMID: 34322894 Free PMC article.

5

Physiologically Based Pharmacokinetic Modeling for Selumetinib to Evaluate Drug-Drug Interactions and Pediatric Dose Regimens.

Cohen-Rabbie S, Zhou L, Vishwanathan K, Wild M, Xu S, Freshwater T, Jain L, Schalkwijk S, Tomkinson H, Zhou D. Cohen-Rabbie S, et al. Among authors: schalkwijk s. J Clin Pharmacol. 2021 Nov;61(11):1493-1504. doi: 10.1002/jcph.1935. Epub 2021 Jul 22. J Clin Pharmacol. 2021. PMID: 34196005 Free PMC article.

6

A phase 1/2 study of the combination of acalabrutinib and vistusertib in patients with relapsed/refractory B-cell malignancies.

Collins GP, Clevenger TN, Burke KA, Yang B, MacDonald A, Cunningham D, Fox CP, Goy A, Gribben J, Nowakowski GS, Roschewski M, Vose JM, Vallurupalli A, Cheung J, Raymond A, Nuttall B, Stetson D, Dougherty BA, Schalkwijk S, Carnevalli LS, Willis B, Tao L, Harrington EA, Hamdy A, Izumi R, Pease JE, Frigault MM, Flinn I. Collins GP, et al. Among authors: schalkwijk s. Leuk Lymphoma. 2021 Nov;62(11):2625-2636. doi: 10.1080/10428194.2021.1938027. Epub 2021 Jul 16. Leuk Lymphoma. 2021. PMID: 34269152 Clinical Trial.

7

A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women.

Schalkwijk S, Ter Heine R, Colbers AC, Huitema ADR, Denti P, Dooley KE, Capparelli E, Best BM, Cressey TR, Greupink R, Russel FGM, Mirochnick M, Burger DM. Schalkwijk S, et al. Clin Pharmacokinet. 2018 Nov;57(11):1421-1433. doi: 10.1007/s40262-018-0642-9. Clin Pharmacokinet. 2018. PMID: 29520730 Free PMC article.

8

Normal fat mass cannot be reliably estimated in typical pharmacokinetic studies.

Wasmann RE, Svensson EM, Schalkwijk SJ, Brüggemann RJ, Ter Heine R. Wasmann RE, et al. Among authors: schalkwijk sj. Eur J Clin Pharmacol. 2021 May;77(5):727-733. doi: 10.1007/s00228-020-03042-4. Epub 2020 Nov 18. Eur J Clin Pharmacol. 2021. PMID: 33205282 Free PMC article.

9

Free dug concentrations in pregnancy: Bound to measure unbound?

Schalkwijk S, Greupink R, Burger D. Schalkwijk S, et al. Br J Clin Pharmacol. 2017 Dec;83(12):2595-2598. doi: 10.1111/bcp.13432. Epub 2017 Oct 6. Br J Clin Pharmacol. 2017. PMID: 28983934 Free PMC article. No abstract available.

10

Assessment of Maternal and Fetal Dolutegravir Exposure by Integrating Ex Vivo Placental Perfusion Data and Physiologically-Based Pharmacokinetic Modeling.

Freriksen JJM, Schalkwijk S, Colbers AP, Abduljalil K, Russel FGM, Burger DM, Greupink R. Freriksen JJM, et al. Among authors: schalkwijk s. Clin Pharmacol Ther. 2020 Jun;107(6):1352-1361. doi: 10.1002/cpt.1748. Epub 2020 Jan 24. Clin Pharmacol Ther. 2020. PMID: 31868223 Free PMC article.

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