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Page 1
Accelerated RNA detection using tandem CRISPR nucleases.
Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, de León Derby MD, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, Stephens SI, Kumar GR, Zhao C, Mok A, Iavarone AT, Escajeda AM, McIntosh R, Kim SE, Dugan EJ; IGI Testing Consortium; Pollard KS, Tan MX, Ott M, Fletcher DA, Lareau LF, Hsu PD, Savage DF, Doudna JA. Liu TY, et al. Among authors: hsu pd. medRxiv [Preprint]. 2021 Mar 24:2021.03.19.21253328. doi: 10.1101/2021.03.19.21253328. medRxiv. 2021. PMID: 33791736 Free PMC article. Updated. Preprint.
Bridge RNAs direct modular and programmable recombination of target and donor DNA.
Durrant MG, Perry NT, Pai JJ, Jangid AR, Athukoralage JS, Hiraizumi M, McSpedon JP, Pawluk A, Nishimasu H, Konermann S, Hsu PD. Durrant MG, et al. Among authors: hsu pd. bioRxiv [Preprint]. 2024 Jan 26:2024.01.24.577089. doi: 10.1101/2024.01.24.577089. bioRxiv. 2024. PMID: 38328150 Free PMC article. Preprint.
Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting.
Wei J, Lotfy P, Faizi K, Baungaard S, Gibson E, Wang E, Slabodkin H, Kinnaman E, Chandrasekaran S, Kitano H, Durrant MG, Duffy CV, Pawluk A, Hsu PD, Konermann S. Wei J, et al. Among authors: hsu pd. Cell Syst. 2023 Dec 20;14(12):1087-1102.e13. doi: 10.1016/j.cels.2023.11.006. Epub 2023 Dec 12. Cell Syst. 2023. PMID: 38091991
The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression.
Wei J, Alfajaro MM, Cai WL, Graziano VR, Strine MS, Filler RB, Biering SB, Sarnik SA, Patel S, Menasche BL, Compton SR, Konermann S, Hsu PD, Orchard RC, Yan Q, Wilen CB. Wei J, et al. Among authors: hsu pd. PLoS Pathog. 2023 Jul 6;19(7):e1011351. doi: 10.1371/journal.ppat.1011351. eCollection 2023 Jul. PLoS Pathog. 2023. PMID: 37410700 Free PMC article.
DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner.
Strine MS, Cai WL, Wei J, Alfajaro MM, Filler RB, Biering SB, Sarnik S, Chow RD, Patil A, Cervantes KS, Collings CK, DeWeirdt PC, Hanna RE, Schofield K, Hulme C, Konermann S, Doench JG, Hsu PD, Kadoch C, Yan Q, Wilen CB. Strine MS, et al. Among authors: hsu pd. PLoS Biol. 2023 Jun 13;21(6):e3002097. doi: 10.1371/journal.pbio.3002097. eCollection 2023 Jun. PLoS Biol. 2023. PMID: 37310920 Free PMC article.
Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade.
Dmello C, Zhao J, Chen L, Gould A, Castro B, Arrieta VA, Zhang DY, Kim KS, Kanojia D, Zhang P, Miska J, Yeeravalli R, Habashy K, Saganty R, Kang SJ, Fares J, Liu C, Dunn G, Bartom E, Schipma MJ, Hsu PD, Alghamri MS, Lesniak MS, Heimberger AB, Rabadan R, Lee-Chang C, Sonabend AM. Dmello C, et al. Among authors: hsu pd. Nat Commun. 2023 Mar 22;14(1):1566. doi: 10.1038/s41467-023-36878-2. Nat Commun. 2023. PMID: 36949040 Free PMC article.
What are the current bottlenecks in developing and applying CRISPR technologies?
Kellogg EH, Gootenberg J, Abudayyeh O, Wong ASL, Dahlman JE, Lapinaite A, Myhrvold C, Liu CC, Hsu PD, Mali P, Qi LS. Kellogg EH, et al. Among authors: hsu pd. Cell Syst. 2022 Aug 17;13(8):589-593. doi: 10.1016/j.cels.2022.07.004. Cell Syst. 2022. PMID: 35981511 Free article. No abstract available.
Rapid detection of SARS-CoV-2 RNA in saliva via Cas13.
Chandrasekaran SS, Agrawal S, Fanton A, Jangid AR, Charrez B, Escajeda AM, Son S, Mcintosh R, Tran H, Bhuiya A, de León Derby MD, Switz NA, Armstrong M, Harris AR, Prywes N, Lukarska M, Biering SB, Smock DCJ, Mok A, Knott GJ, Dang Q, Van Dis E, Dugan E, Kim S, Liu TY; IGI Testing Consortium; Moehle EA, Kogut K, Eskenazi B, Harris E, Stanley SA, Lareau LF, Tan MX, Fletcher DA, Doudna JA, Savage DF, Hsu PD. Chandrasekaran SS, et al. Among authors: hsu pd. Nat Biomed Eng. 2022 Aug;6(8):944-956. doi: 10.1038/s41551-022-00917-y. Epub 2022 Aug 11. Nat Biomed Eng. 2022. PMID: 35953650 Free PMC article.
37 results