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Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk.
Chiou J, Zeng C, Cheng Z, Han JY, Schlichting M, Miller M, Mendez R, Huang S, Wang J, Sui Y, Deogaygay A, Okino ML, Qiu Y, Sun Y, Kudtarkar P, Fang R, Preissl S, Sander M, Gorkin DU, Gaulton KJ. Chiou J, et al. Among authors: fang r. Nat Genet. 2021 Apr;53(4):455-466. doi: 10.1038/s41588-021-00823-0. Epub 2021 Apr 1. Nat Genet. 2021. PMID: 33795864 Free PMC article.
Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation.
Preissl S, Fang R, Huang H, Zhao Y, Raviram R, Gorkin DU, Zhang Y, Sos BC, Afzal V, Dickel DE, Kuan S, Visel A, Pennacchio LA, Zhang K, Ren B. Preissl S, et al. Among authors: fang r. Nat Neurosci. 2018 Mar;21(3):432-439. doi: 10.1038/s41593-018-0079-3. Epub 2018 Feb 12. Nat Neurosci. 2018. PMID: 29434377 Free PMC article.
Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells.
Zhang Y, Li T, Preissl S, Amaral ML, Grinstein JD, Farah EN, Destici E, Qiu Y, Hu R, Lee AY, Chee S, Ma K, Ye Z, Zhu Q, Huang H, Fang R, Yu L, Izpisua Belmonte JC, Wu J, Evans SM, Chi NC, Ren B. Zhang Y, et al. Among authors: fang r. Nat Genet. 2019 Sep;51(9):1380-1388. doi: 10.1038/s41588-019-0479-7. Epub 2019 Aug 19. Nat Genet. 2019. PMID: 31427791 Free PMC article.
Spatiotemporal DNA methylome dynamics of the developing mouse fetus.
He Y, Hariharan M, Gorkin DU, Dickel DE, Luo C, Castanon RG, Nery JR, Lee AY, Zhao Y, Huang H, Williams BA, Trout D, Amrhein H, Fang R, Chen H, Li B, Visel A, Pennacchio LA, Ren B, Ecker JR. He Y, et al. Among authors: fang r. Nature. 2020 Jul;583(7818):752-759. doi: 10.1038/s41586-020-2119-x. Epub 2020 Jul 29. Nature. 2020. PMID: 32728242 Free PMC article.
Chromothripsis drives the evolution of gene amplification in cancer.
Shoshani O, Brunner SF, Yaeger R, Ly P, Nechemia-Arbely Y, Kim DH, Fang R, Castillon GA, Yu M, Li JSZ, Sun Y, Ellisman MH, Ren B, Campbell PJ, Cleveland DW. Shoshani O, et al. Among authors: fang r. Nature. 2021 Mar;591(7848):137-141. doi: 10.1038/s41586-020-03064-z. Epub 2020 Dec 23. Nature. 2021. PMID: 33361815 Free PMC article.
Comprehensive analysis of single cell ATAC-seq data with SnapATAC.
Fang R, Preissl S, Li Y, Hou X, Lucero J, Wang X, Motamedi A, Shiau AK, Zhou X, Xie F, Mukamel EA, Zhang K, Zhang Y, Behrens MM, Ecker JR, Ren B. Fang R, et al. Nat Commun. 2021 Feb 26;12(1):1337. doi: 10.1038/s41467-021-21583-9. Nat Commun. 2021. PMID: 33637727 Free PMC article.
1,931 results